Composites of graphene oxide and gold Nanospheres: A dual-targeted Recognition and dual-responsive release Chemophotothermal therapeutic platform

IF 4.2 2区工程技术 Q2 ENGINEERING, CHEMICAL

Advanced Powder Technology Pub Date : 2025-04-03 DOI:10.1016/j.apt.2025.104874

Yijie Wang , Ruolan Feng , Meijuan Shi , Huirui Zhu , Moxuan Zhao , Jinyu Li , Hongqin Wang , Xiaoning Li , Tao Gong , Rui Guo

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Abstract

The negative effects of conventional chemotherapy have been significantly reduced in the past several years by the widespread use of nanomedicine delivery systems in conjunction with conventional liver cancer treatments. This study reports the construction of a novel multifunctional nanocomposite by attaching folic acid (FA) and triformylcholic acid (TCA) to the surface of graphene oxide-gold nanospheres (GO-AuNSs). Doxorubicin hydrochloride (DOX) was used as a model drug to form GO-AuNSs-FA-TCA@DOX on GO-AuNSs-FA-TCA, which has excellent photothermal conversion efficiency, dual-targeted drug delivery, endogenous tumor microenvironment (TME) and near-infrared light (NIR) dual-responsive drug release. More importantly, in vitro and in vivo experiments have shown that the combination therapy shows a higher therapeutic effect than chemotherapy or photothermal therapy alone. Compared with normal cells and other cancer cells, the treatment effect of liver cancer cells is stronger. Therefore, the new nano drug carrier synthesized in this paper has potential application value in the combination therapy of liver cancer.

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氧化石墨烯与金纳米球复合材料：双目标识别和双响应释放的化学光热治疗平台

在过去几年中，由于纳米药物输送系统与传统肝癌治疗相结合的广泛使用，传统化疗的负面影响已显著减少。本研究报道了将叶酸（FA）和三甲酰胆酸（TCA）附着在氧化石墨烯-金纳米球（GO-AuNSs）表面，构建了一种新型多功能纳米复合材料。以多柔比星（DOX）为模型药物，在GO-AuNSs-FA-TCA上形成GO-AuNSs-FA-TCA@DOX，具有优异的光热转化效率、双靶向给药、内源性肿瘤微环境（TME）和近红外光（NIR）双响应的药物释放。更重要的是，体外和体内实验表明，联合治疗比单独化疗或光热治疗有更高的治疗效果。与正常细胞和其他癌细胞相比，肝癌细胞的治疗效果更强。因此，本文合成的新型纳米药物载体在肝癌的联合治疗中具有潜在的应用价值。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Advanced Powder Technology 工程技术-工程：化工

CiteScore

9.50

自引率

7.70%

发文量

424

审稿时长

55 days

期刊介绍： The aim of Advanced Powder Technology is to meet the demand for an international journal that integrates all aspects of science and technology research on powder and particulate materials. The journal fulfills this purpose by publishing original research papers, rapid communications, reviews, and translated articles by prominent researchers worldwide. The editorial work of Advanced Powder Technology, which was founded as the International Journal of the Society of Powder Technology, Japan, is now shared by distinguished board members, who operate in a unique framework designed to respond to the increasing global demand for articles on not only powder and particles, but also on various materials produced from them. Advanced Powder Technology covers various areas, but a discussion of powder and particles is required in articles. Topics include: Production of powder and particulate materials in gases and liquids(nanoparticles, fine ceramics, pharmaceuticals, novel functional materials, etc.); Aerosol and colloidal processing; Powder and particle characterization; Dynamics and phenomena; Calculation and simulation (CFD, DEM, Monte Carlo method, population balance, etc.); Measurement and control of powder processes; Particle modification; Comminution; Powder handling and operations (storage, transport, granulation, separation, fluidization, etc.)