Optimization, validation, and implementation of a new method for detecting liquid crystal monomers in dust using GC−MS/MS with atmospheric pressure chemical ionization

IF 5.7 2区化学 Q1 CHEMISTRY, ANALYTICAL

Analytica Chimica Acta Pub Date : 2025-04-01 DOI:10.1016/j.aca.2025.344002

Jing Han , Jun Liu , Huiyuan Lu , Kehan Guo , Fei Zhang , Shujie Guo , Xianfa Su , Shuying Dong , Jianhui Sun , Jinglan Feng , Taicheng An

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引用次数: 0

Abstract

Background

Liquid crystal monomers (LCMs) are a new class of emerging pollutants. To assess their occurrence, behaviour, and potential risks, a sensitive and selective analytical method is required for the determination of LCMs at trace levels in multiple environmental media. Toward this end, an improved GC−MS/MS method was developed and validated for the quantification of LCMs.

Results

The method integrates atmospheric pressure chemical ionization (APCI) with GC−MS/MS. Under optimal instrumental conditions, the instrument quantification limits of LCMs reached as low as 0.02 pg·injection⁻¹, which can be attributed to the generation of high-abundance molecular ions/quasi-molecular ions under APCI. Compared to previously published methods, the developed method in this study reduces the method detection limits of LCMs by approximately 1–38.7 times, enabling the analysis of LCMs at concentrations as low as 0.02 ng·g⁻¹ in dust samples. This improved approach was applied to both indoor and outdoor dust samples. The concentrations of LCMs obtained in this study are consistent with those reported in previous research, demonstrating high detection frequencies of fluorinated LCMs and their predominance in dust.

Significance

The developed method in this study is not only applicable to dust samples but also readily extends to other environmental matrices, thereby facilitating the investigation of the occurrence, origin, and migration of LCMs in various environments.

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来源期刊

Analytica Chimica Acta 化学-分析化学

CiteScore

10.40

自引率

6.50%

发文量

1081

审稿时长

38 days

期刊介绍： Analytica Chimica Acta has an open access mirror journal Analytica Chimica Acta: X, sharing the same aims and scope, editorial team, submission system and rigorous peer review. Analytica Chimica Acta provides a forum for the rapid publication of original research, and critical, comprehensive reviews dealing with all aspects of fundamental and applied modern analytical chemistry. The journal welcomes the submission of research papers which report studies concerning the development of new and significant analytical methodologies. In determining the suitability of submitted articles for publication, particular scrutiny will be placed on the degree of novelty and impact of the research and the extent to which it adds to the existing body of knowledge in analytical chemistry.