{"title":"O-GlcNAc transferase is a key regulator of DNA methylation and transposon silencing","authors":"","doi":"10.1038/s41594-025-01507-7","DOIUrl":null,"url":null,"abstract":"Disruption of the enzyme O-GlcNAc transferase in mouse embryonic stem cells unleashes the activity of TET enzymes, which cause genome-wide decreases in DNA methylation and increases in DNA hydroxymethylation. This leads to de-repression of transposable elements, as well as the activation of some nearby genes.","PeriodicalId":18822,"journal":{"name":"Nature structural & molecular biology","volume":"32 1","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2025-04-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Nature structural & molecular biology","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1038/s41594-025-01507-7","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0
Abstract
Disruption of the enzyme O-GlcNAc transferase in mouse embryonic stem cells unleashes the activity of TET enzymes, which cause genome-wide decreases in DNA methylation and increases in DNA hydroxymethylation. This leads to de-repression of transposable elements, as well as the activation of some nearby genes.
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