Enhanced Mesenchymal Stem Cells-derived Exosomes Secretion by Electrical Stimulation of Triboelectric Nanogenerator

IF 16.8 1区材料科学 Q1 CHEMISTRY, PHYSICAL

Nano Energy Pub Date : 2025-04-01 DOI:10.1016/j.nanoen.2025.110933

Shanguo Zhang , Tianyi Jiang , Haoxiu Sun , Ming Li , Depeng Yang , Wenlong Wu , Qi Gu , Aitong Xu , Yu Li , Hongyuan Jiang

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引用次数: 0

Abstract

Exosomes derived from mesenchymal stem cells (MSCs) exhibit immunomodulatory, tissue repair, anti-inflammatory, and anti-aging properties, making them valuable tools in cell therapy and regenerative medicine. Electrical stimulation shows promise for enhancing exosome production; however, current methods rely on large, expensive power supplies to generate electrical signals. These systems are prone to electrode electrolysis and bubble formation in the buffer solution. In this study, we propose a novel self-powered method based on triboelectric nanogenerators to enhance exosome production from MSCs. This approach utilizes the triboelectric effect to generate an electrical output with an open-circuit voltage of 1800V and a short-circuit current of 88 µA, effectively avoiding harmful electrochemical reactions. By optimizing parameters such as current strength, electrical stimulation duration, and treatment cycles, exosome production is increased by up to 3.2 times. Further investigations reveal that the enhanced exosome production is closely linked to calcium ion influx. Moreover, exosomes produced under electrical stimulation retain their biological activity and significantly promote wound healing. Thus, this self-powered, portable, and efficient electrical stimulation method holds significant potential for advancing exosome production.

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来源期刊

Nano Energy CHEMISTRY, PHYSICAL-NANOSCIENCE & NANOTECHNOLOGY

CiteScore

30.30

自引率

7.40%

发文量

1207

审稿时长

23 days

期刊介绍： Nano Energy is a multidisciplinary, rapid-publication forum of original peer-reviewed contributions on the science and engineering of nanomaterials and nanodevices used in all forms of energy harvesting, conversion, storage, utilization and policy. Through its mixture of articles, reviews, communications, research news, and information on key developments, Nano Energy provides a comprehensive coverage of this exciting and dynamic field which joins nanoscience and nanotechnology with energy science. The journal is relevant to all those who are interested in nanomaterials solutions to the energy problem. Nano Energy publishes original experimental and theoretical research on all aspects of energy-related research which utilizes nanomaterials and nanotechnology. Manuscripts of four types are considered: review articles which inform readers of the latest research and advances in energy science; rapid communications which feature exciting research breakthroughs in the field; full-length articles which report comprehensive research developments; and news and opinions which comment on topical issues or express views on the developments in related fields.