Introducing the aziridination of fluorinated olefins by metal-catalyzed nitrene transfer

Abstract

After decades of development of the metal-catalyzed nitrene transfer reactions to olefins, examples involving the use of fluorinated olefins is yet unknown, despite the current importance of fluorocompounds. Herein we describe the use of copper- and silver-based catalysts for a general protocol that converts α− or β-fluoro olefins into the corresponding aziridines in high yields.