Low-frequency ultrasound-driven piezoelectric films repair neuro-immune circuits in diabetic wound healing

IF 13.3 1区工程技术 Q1 ENGINEERING, CHEMICAL

Chemical Engineering Journal Pub Date : 2025-04-01 DOI:10.1016/j.cej.2025.162045

Chenyan Yu, Ying Hu, Xin Zhang, Kaixu Yu, Lang Chen, Wenqian Zhang, Shengming Zhang, Zhenhe Zhang, Ruiyin Zeng, Yuheng Liao, Yanzhi Zhao, Lin Gan, Faqi Cao, Hui Li, Bobin Mi, Guohui Liu

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引用次数: 0

Abstract

Neuronal regeneration and immune modulation are critical for functional healing in diabetic wounds, yet existing wound treatments fail to address the complex interplay between these processes. This study introduces an effective cellular, cytokine-free therapeutic approach utilizing MXene/PVDF film for diabetic wound healing, driven by low-frequency ultrasound. These films provide localized electrical stimulation to enhance axonal regeneration and modulate immune responses within the wound microenvironment. Mechanistically, low-frequency ultrasound-activated MXene/PVDF films significantly promote axonal growth of dorsal root ganglion (DRG) explants, which, through the increased secretion of calcitonin gene-related peptide (CGRP) by peptidergic neurons, induce M2 macrophage polarization, thereby establishing neuro-immune circuits under hyperglycemic conditions. Macrophage depletion further confirms the crucial role of macrophages in facilitating neuronal regeneration. In vivo, the ultrasound-driven MXene/PVDF film accelerates wound healing, supports epidermal nerve regeneration and M2 macrophage polarization, and restores sensory function in diabetic wounds. These findings highlight the potential of MXene/PVDF films, coupled with ultrasound stimulation, as a promising therapeutic strategy for enhancing neuronal repair and immune modulation in diabetic wound healing.

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来源期刊

Chemical Engineering Journal 工程技术-工程：化工

CiteScore

21.70

自引率

9.30%

发文量

6781

审稿时长

2.4 months

期刊介绍： The Chemical Engineering Journal is an international research journal that invites contributions of original and novel fundamental research. It aims to provide an international platform for presenting original fundamental research, interpretative reviews, and discussions on new developments in chemical engineering. The journal welcomes papers that describe novel theory and its practical application, as well as those that demonstrate the transfer of techniques from other disciplines. It also welcomes reports on carefully conducted experimental work that is soundly interpreted. The main focus of the journal is on original and rigorous research results that have broad significance. The Catalysis section within the Chemical Engineering Journal focuses specifically on Experimental and Theoretical studies in the fields of heterogeneous catalysis, molecular catalysis, and biocatalysis. These studies have industrial impact on various sectors such as chemicals, energy, materials, foods, healthcare, and environmental protection.