Is There an Alternative “Advanced Maternal Age” Threshold for Recommendation of Invasive Prenatal Testing?

Abstract

This retrospective cohort study aimed to examine the appropriate maternal age threshold for recommendation of invasive prenatal testing. We calculated the rate of clinically significant microarray findings in pregnancies with normal fetal ultrasound per each year of maternal age, to estimate the optimal cut-off. Of the 7033 prenatal microarray analyses, 108 (1.53%) clinically significant results were noted. Receiver operating characteristics analysis failed to define a specific maternal age cut-off, in the overall cohort as well following the omission of non-invasive prenatal screening-detectable common autosomal trisomies. This implies that each woman should be offered the possibility of invasive testing, preferably publicly funded.