Nathaniel G Harnett, Soumyaa Joshi, Poornima Kumar, Courtney Russell, Daniel G Dillon, Justin T Baker, Diego A Pizzagalli, Milissa L Kaufman, Lisa N Nickerson, Neda Jahanshad, Lauren E Salminen, Sophia I Thomopoulos, Jessie L Frijling, Dick J Veltman, Saskia B J Koch, Laura Nawijn, Mirjam van Zuiden, Ye Zhu, Gen Li, Jonathan Ipser, Xi Zhu, Orren Ravid, Sigal Zilcha-Mano, Amit Lazarov, Benjamin Suarez-Jimenez, Delin Sun, Ahmed Hussain, Ashley A Huggins, Tanja Jovanovic, Sanne J H van Rooij, Negar Fani, Anna R Hudson, Anika Sierk, Antje Manthey, Henrik Walter, Nic J A van der Wee, Steven J A van der Werff, Robert R J M Vermeiren, Pavel Říha, Lauren A M Lebois, Isabelle M Rosso, Elizabeth A Olson, Israel Liberzon, Mike Angstadt, Seth G Disner, Scott R Sponheim, Sheri-Michelle Koopowitz, David Hofmann, Rongfeng Qi, Adi Maron-Katz, Austin Kunch, Hong Xie, Wissam El-Hage, Hannah Berg, Steven E Bruce, Katie A McLaughlin, Matthew Peverill, Kelly Sambrook, Marisa Ross, Ryan J Herringa, Jack B Nitschke, Richard J Davidson, Terri A deRoon-Cassini, Carissa W Tomas, Jacklynn M Fitzgerald, Jennifer Urbano Blackford, Bunmi O Olatunji, Steven M Nelson, Evan M Gordon, Maria Densmore, Jean Théberge, Richard W J Neufeld, Miranda Olff, Li Wang, Dan J Stein, Yuval Neria, Jennifer S Stevens, Sven C Mueller, Judith K Daniels, Ivan Rektor, Anthony King, Nicholas D Davenport, Thomas Straube, Guangming Lu, Amit Etkin, Xin Wang, Yann Quidé, Shmuel Lissek, Josh Cisler, Daniel W Grupe, Christine Larson, Brandee Feola, Geoffrey May, Chadi G Abdallah, Ruth Lanius, Paul M Thompson, Rajendra A Morey, Kerry Ressler
{"title":"Structural covariance of early visual cortex is negatively associated with PTSD symptoms: A Mega-Analysis from the ENIGMA PTSD workgroup.","authors":"Nathaniel G Harnett, Soumyaa Joshi, Poornima Kumar, Courtney Russell, Daniel G Dillon, Justin T Baker, Diego A Pizzagalli, Milissa L Kaufman, Lisa N Nickerson, Neda Jahanshad, Lauren E Salminen, Sophia I Thomopoulos, Jessie L Frijling, Dick J Veltman, Saskia B J Koch, Laura Nawijn, Mirjam van Zuiden, Ye Zhu, Gen Li, Jonathan Ipser, Xi Zhu, Orren Ravid, Sigal Zilcha-Mano, Amit Lazarov, Benjamin Suarez-Jimenez, Delin Sun, Ahmed Hussain, Ashley A Huggins, Tanja Jovanovic, Sanne J H van Rooij, Negar Fani, Anna R Hudson, Anika Sierk, Antje Manthey, Henrik Walter, Nic J A van der Wee, Steven J A van der Werff, Robert R J M Vermeiren, Pavel Říha, Lauren A M Lebois, Isabelle M Rosso, Elizabeth A Olson, Israel Liberzon, Mike Angstadt, Seth G Disner, Scott R Sponheim, Sheri-Michelle Koopowitz, David Hofmann, Rongfeng Qi, Adi Maron-Katz, Austin Kunch, Hong Xie, Wissam El-Hage, Hannah Berg, Steven E Bruce, Katie A McLaughlin, Matthew Peverill, Kelly Sambrook, Marisa Ross, Ryan J Herringa, Jack B Nitschke, Richard J Davidson, Terri A deRoon-Cassini, Carissa W Tomas, Jacklynn M Fitzgerald, Jennifer Urbano Blackford, Bunmi O Olatunji, Steven M Nelson, Evan M Gordon, Maria Densmore, Jean Théberge, Richard W J Neufeld, Miranda Olff, Li Wang, Dan J Stein, Yuval Neria, Jennifer S Stevens, Sven C Mueller, Judith K Daniels, Ivan Rektor, Anthony King, Nicholas D Davenport, Thomas Straube, Guangming Lu, Amit Etkin, Xin Wang, Yann Quidé, Shmuel Lissek, Josh Cisler, Daniel W Grupe, Christine Larson, Brandee Feola, Geoffrey May, Chadi G Abdallah, Ruth Lanius, Paul M Thompson, Rajendra A Morey, Kerry Ressler","doi":"10.1101/2025.03.18.25324188","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>Identifying robust neural signatures of posttraumatic stress disorder (PTSD) symptoms is important to facilitate precision psychiatry and help in understanding and treatment of the disorder. Emergent research suggests structural covariance of early visual regions is associated with later PTSD development. However, large-scale analyses are needed - in heterogeneous samples of trauma-exposed and trauma naive individuals - to determine if such a neural signature is a robust - and potentially a pretrauma - marker of vulnerability.</p><p><strong>Methods: </strong>We analyzed data from the ENIGMA-PTSD dataset (n = 2,814) and the Human Connectome Project - Young Adult (HCP-YA) dataset (n = 890) to investigate whether structural covariance of early visual cortex is associated with either PTSD symptoms or perceived stress. Structural covariance was derived from a multimodal pattern previously identified in recent trauma survivors, and participant loadings on the profile were included in linear mixed effects models to evaluate associations with stress.</p><p><strong>Results: </strong>Early visual cortex covariance loadings were negatively associated with PTSD symptoms in the ENIGMA-PTSD dataset. The relationship persisted when accounting for prior childhood maltreatment; supporting PTSD symptom specificity, no relationship was observed with depressive symptoms and no association was observed between loadings and perceived stress measures in the HCP-YA dataset.</p><p><strong>Conclusion: </strong>Structural covariance of early visual cortex was robustly associated with PTSD symptoms across an international, heterogeneous sample of trauma survivors. Future studies should aim to identify specific mechanisms that underlie structural alterations in the visual cortex to better understand posttrauma psychopathology.</p>","PeriodicalId":94281,"journal":{"name":"medRxiv : the preprint server for health sciences","volume":" ","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2025-03-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11957098/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"medRxiv : the preprint server for health sciences","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1101/2025.03.18.25324188","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0
Abstract
Background: Identifying robust neural signatures of posttraumatic stress disorder (PTSD) symptoms is important to facilitate precision psychiatry and help in understanding and treatment of the disorder. Emergent research suggests structural covariance of early visual regions is associated with later PTSD development. However, large-scale analyses are needed - in heterogeneous samples of trauma-exposed and trauma naive individuals - to determine if such a neural signature is a robust - and potentially a pretrauma - marker of vulnerability.
Methods: We analyzed data from the ENIGMA-PTSD dataset (n = 2,814) and the Human Connectome Project - Young Adult (HCP-YA) dataset (n = 890) to investigate whether structural covariance of early visual cortex is associated with either PTSD symptoms or perceived stress. Structural covariance was derived from a multimodal pattern previously identified in recent trauma survivors, and participant loadings on the profile were included in linear mixed effects models to evaluate associations with stress.
Results: Early visual cortex covariance loadings were negatively associated with PTSD symptoms in the ENIGMA-PTSD dataset. The relationship persisted when accounting for prior childhood maltreatment; supporting PTSD symptom specificity, no relationship was observed with depressive symptoms and no association was observed between loadings and perceived stress measures in the HCP-YA dataset.
Conclusion: Structural covariance of early visual cortex was robustly associated with PTSD symptoms across an international, heterogeneous sample of trauma survivors. Future studies should aim to identify specific mechanisms that underlie structural alterations in the visual cortex to better understand posttrauma psychopathology.
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