Status of Fasting Serum Glucose and Serum Magnesium among Women Having Low Dose Oral Contraceptive Pill.

Abstract

Low dose oral contraceptives are a major category of prescription drugs used by a large number of reproductive women. Since the introduction of the first combined oral contraceptives in the 1960s, great progress has been made to reduce side effects and improve tolerability without compromising efficacy. The most commonly used are combinations of drugs that contain both estrogen and progesterone. Long-term use of hormonal contraceptives by women of reproductive age can lead to metabolic changes that may contribute to an alteration in many biochemical parameters. The aim of this study was to estimate the status of fasting serum glucose and serum magnesium in low dose oral contraceptive pill (OCP) users in Mymensingh locality. This cross-sectional analytical type of study was conducted in the Department of Physiology, Mymensingh Medical College, Bangladesh from July 2023 to June 2024. A total number of 140 reproductive women, age ranged from 18-52 years was included in this study. Among them 70 (seventy) low dose oral contraceptive pill non users were taken as control group (Group I) and 70 (seventy) low dose oral contraceptive pill users were taken as study group (Group II). The results were calculated and analyzed by using SPSS, version 26.0. Laboratory analysis of fasting serum glucose by GOD-PAP method and serum magnesium by enzymatic colorimetric method. Data were expressed in Mean±SD and statistical significance of difference among the groups was calculated by unpaired Student's 't' test. The mean±SD of fasting serum glucose of control group and study group were 4.89±0.62 and 7.19±0.98 mmol/L respectively. In study group fasting serum glucose was increased in comparison to control group. The mean±SD of serum magnesium of control group and study group were 1.91±0.19 and 1.45±0.18 mg/dl respectively. In study group serum magnesium was decreased in comparison to control group. In this study, fasting serum glucose and serum magnesium was statistically significant (p<0.001) in study group in comparison to control group. Therefore, by this study we recommended that OCP users should follow up by testing of these parameters for regular assessment to prevent metabolic disorders and hypomagnesaemia.