Application of plant-derived extracellular vesicles as novel carriers in drug delivery systems: a review.

Expert opinion on drug delivery Pub Date : 2025-06-01 Epub Date: 2025-04-03 DOI:10.1080/17425247.2025.2487589
Jiayi Yang, Xinyi Ai, Chenming Zhang, Teng Guo, Nianping Feng
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Abstract

Introduction: Plant-derived extracellular vesicles (P-EVs) are nanoscale, lipid bilayer vesicles capable of transporting diverse bioactive substances, enabling intercellular and interspecies communication and material transfer. With inherent pharmacological effects, targeting abilities, high safety, biocompatibility, and low production costs, P-EVs are promising candidates for drug delivery systems, offering significant application potential.

Areas covered: A comprehensive review of studies on P-EVs was conducted through extensive database searches, including PubMed and Web of Science, spanning the years 1959 to 2025. Drawing on animal and cellular model research, this review systematically analyzes the pharmacological activities of P-EVs and their advantages as drug delivery carriers. It also explores P-EVs' drug loading methods, extraction techniques, and application prospects, including their benefits, clinical potential, and feasibility for commercial expansion.

Expert opinion: Establishing unified preparation standards and conducting a more comprehensive analysis of molecular composition, structural characteristics, and mechanisms of P-EVs are essential for their widespread application. Greater attention should be given to the potential synergistic or antagonistic effects between P-EVs as carriers and the drugs they deliver, as this understanding will enhance their practical applications. In conclusion, P-EVs-based drug delivery systems represent a promising strategy to improve treatment efficacy, reduce side effects, and ensure drug stability.

植物源性细胞外囊泡作为新型载体在药物传递系统中的应用综述。
植物源性细胞外囊泡(p - ev)是一种纳米级的脂质双层囊泡,能够运输多种生物活性物质,实现细胞间和物种间的交流和物质转移。p - ev具有固有的药理作用、靶向能力、高安全性、生物相容性和低生产成本,是很有前途的药物输送系统候选者,具有巨大的应用潜力。涵盖领域:通过广泛的数据库搜索,包括PubMed和Web of Science,对1959年至2025年的p - ev研究进行了全面的回顾。本文通过动物和细胞模型研究,系统分析了p - ev的药理活性及其作为药物传递载体的优势。探讨了p - ev的载药方法、提取技术和应用前景,包括其益处、临床潜力和商业推广的可行性。专家意见:建立统一的制备标准,对p - ev的分子组成、结构特征和作用机理进行更全面的分析是其广泛应用的必要条件。应该更多地关注作为载体的p - ev与它们递送的药物之间潜在的协同或拮抗作用,因为这种理解将增强它们的实际应用。总之,基于p - ev的给药系统是一种很有前途的策略,可以提高治疗效果,减少副作用,并确保药物稳定性。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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