Cerebrospinal fluid cytokine levels affect electroencephalographic activity in Alzheimer's disease.

IF 2.8 Q2 NEUROSCIENCES

Journal of Alzheimer's disease reports Pub Date : 2025-03-28 eCollection Date: 2025-01-01 DOI:10.1177/25424823241306772

Matilde Bruno, Chiara Giuseppina Bonomi, Alessandro Castelli, Francesca Izzi, Fabio Placidi, Silvia Falletti, Nicola Biagio Mercuri, Caterina Motta, Alessandro Martorana

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Abstract

To investigate the role of neuroinflammation as mediator of amyloid-β-induced cortical activity changes in Alzheimer's disease (AD), we examined the relationship between cerebrospinal fluid (CSF) inflammatory cytokines (IL-1β, IL-2, IL-4, IL-6, IL-7, IL-8, IL-10, IL-12, IL-13, IL-17, TNF-α, IFN-γ, GM-CSF, G-CSF, MIP-1α, MCP-1) and electroencephalographic (EEG) abnormalities in a cohort of biologically defined AD patients (n = 55, M:F = 19:36, median age 73, Mini-Mental State Examination ≥ 22). We retrieved a positive association between IL-4 CSF levels and EEG background activity frequency; IL-7, IL-8, and IL-12 CSF levels were positively associated with the presence of interictal epileptiform discharges. Neuroinflammation accompanying AD pathology may enhance the amyloid's epileptogenic potential while also counteracting neurodegenerative damage.

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脑脊液细胞因子水平影响阿尔茨海默病的脑电图活动。

为了研究神经炎症在淀粉样蛋白β诱导的阿尔茨海默病（AD）皮层活性变化中的中介作用，我们在生物学定义的AD患者队列（n = 55, M:F = 19:36，中位年龄73，最小精神状态检查≥22）中检测了脑脊液（CSF）炎症因子（IL-1β, IL-2, IL-4, IL-6, IL-7, IL-8, IL-10, IL-12, IL-13, IL-17, TNF-α, IFN-γ, gmcsf, G-CSF, MIP-1α, MCP-1）与脑电图（EEG）异常之间的关系。我们发现IL-4 CSF水平与脑电图背景活动频率呈正相关；脑脊液IL-7、IL-8和IL-12水平与发作间期癫痫样放电呈正相关。伴随AD病理的神经炎症可能增强淀粉样蛋白的致痫潜能，同时也抵消神经退行性损伤。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Alzheimer's disease reports

CiteScore

2.80

自引率

0.00%

发文量