Obesity and sexual desire: a systematic review and meta-analysis.

IF 3.3 3区 医学 Q1 UROLOGY & NEPHROLOGY
Małgorzata Biernikiewicz, Agnieszka Rusiecka, Dariusz Kałka
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引用次数: 0

Abstract

Background: Impaired sexual functioning is one of the consequences of obesity with hormonal disorders involving testosterone.

Aim: To explore the link between obesity and sexual desire, to assess how changes in body weight affect sexual desire, and to examine the role of testosterone in these changes in obese and overweight men.

Methods: The systematic review was conducted in PubMed. Studies involving obese/overweight men that reported different libido levels or changes after weight loss interventions were included. Meta-analysis and meta-regression were performed.

Results: The search identified 2259 studies, of which 28 met the eligibility criteria. Most studies focused on weight-loss interventions (n = 21, 77%), with 13 studies investigating the effect of bariatric surgeries. Testosterone levels were reported in 14 studies. The studies encompassed a total population of 18 653 people, including 10 356 obese and overweight men. Of the 28 identified studies, 15 indicated a potential association between BMI, waist circumference, and sexual desire. Effect size meta-analysis (calculated using data from four studies presenting results before and after bariatric surgery) suggests that an increase in the International Index of Erectile Function sexual desire domain was very strongly associated with changes in a patients' weight resulting from bariatric surgery (d = 1.22, 95% CI 0.41-2.03, P = 0.003). The meta-analysis of four studies, presenting results before and after diet intervention, showed a strong impact of weight loss on an increase of the Sexual Desire Inventory (SDI), (d = 1.16, 95% CI 0.44-1.88, P = 0.002) The meta-regression revealed a significant association between the level of sexual desire on the SDI and the magnitude of BMI changes before and after dieting interventions (R2 = 77.97%; P = 0.002). The meta-analysis of plasma total testosterone levels from studies that present results before and after selected diets showed a strong impact of diet on the increase in testosterone levels after interventions (d = 1.39 95% CI 0.86-1.92; P < 0.001). There was a significant impact of the level of plasma total testosterone on the variance of sexual desire in the SDI questionnaire (R2 = 5.33%; P < 0.001).

Limitations of evidence: A lack of studies that focus on sexual desire in obesity, the heterogeneity of the included population, the variability in the used questionnaires and reported statistics.

Conclusions: A potential association between sexual desire and body weight exists. Weight loss interventions, including dietary changes and bariatric surgery, significantly increased both sexual desire and plasma total testosterone levels. Additionally, variations in plasma total testosterone levels had a significant effect on the variability of sexual desire in obese men.

背景:目的:探讨肥胖与性欲之间的联系,评估体重变化如何影响性欲,并研究睾酮在肥胖和超重男性性欲变化中的作用:方法:在 PubMed 上进行系统综述。方法:在 PubMed 上进行了系统综述,纳入了涉及肥胖/超重男性的研究,这些研究报告了不同的性欲水平或减肥干预后的变化。结果:共检索到 2259 项研究,其中有 6 项研究的性欲水平在减肥干预措施后发生了变化,有 3 项研究的性欲水平在减肥干预措施后发生了变化:结果:搜索发现了 2259 项研究,其中 28 项符合资格标准。大多数研究侧重于减肥干预措施(n = 21,77%),其中 13 项研究调查了减肥手术的效果。有 14 项研究报告了睾酮水平。这些研究共涉及 18 653 人,其中包括 10 356 名肥胖和超重男性。在已确定的 28 项研究中,15 项研究表明体重指数、腰围和性欲之间存在潜在联系。效应大小荟萃分析(利用四项研究的数据计算得出减肥手术前后的结果)表明,国际勃起功能指数性欲领域的增加与减肥手术导致的患者体重变化密切相关(d = 1.22,95% CI 0.41-2.03,P = 0.003)。元回归显示,SDI 的性欲水平与节食干预前后体重指数的变化幅度之间存在显著关联(R2 = 77.97%;P = 0.002)。对提供选定节食前后结果的研究的血浆总睾酮水平进行的荟萃分析表明,节食对干预后睾酮水平的增加有很大影响(d = 1.39 95% CI 0.86-1.92;P 证据的局限性:缺乏关注肥胖症患者性欲的研究、纳入人群的异质性、使用的问卷和报告的统计数据存在差异:结论:性欲与体重之间存在潜在联系。结论:性欲与体重之间存在着潜在的联系。减肥干预措施,包括改变饮食习惯和减肥手术,可显著提高性欲和血浆总睾酮水平。此外,血浆总睾酮水平的变化对肥胖男性性欲的变化也有显著影响。
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来源期刊
Journal of Sexual Medicine
Journal of Sexual Medicine 医学-泌尿学与肾脏学
CiteScore
6.20
自引率
5.70%
发文量
826
审稿时长
2-4 weeks
期刊介绍: The Journal of Sexual Medicine publishes multidisciplinary basic science and clinical research to define and understand the scientific basis of male, female, and couples sexual function and dysfunction. As an official journal of the International Society for Sexual Medicine and the International Society for the Study of Women''s Sexual Health, it provides healthcare professionals in sexual medicine with essential educational content and promotes the exchange of scientific information generated from experimental and clinical research. The Journal of Sexual Medicine includes basic science and clinical research studies in the psychologic and biologic aspects of male, female, and couples sexual function and dysfunction, and highlights new observations and research, results with innovative treatments and all other topics relevant to clinical sexual medicine. The objective of The Journal of Sexual Medicine is to serve as an interdisciplinary forum to integrate the exchange among disciplines concerned with the whole field of human sexuality. The journal accomplishes this objective by publishing original articles, as well as other scientific and educational documents that support the mission of the International Society for Sexual Medicine.
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