Unveiling the Enigma: Gigantic primary de novo poorly-differentiated ductal adenocarcinoma of the lacrimal gland with aggressive features. A case report and literature review.

S Malik, C Ahluwalia, A Aziz Khan
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引用次数: 0

Abstract

Primary ductal adenocarcinoma (PDA) of the lacrimal gland is a rare and aggressive malignancy originating from ductal epithelial cells. Its rarity and diverse clinical presentations pose significant diagnostic challenges, emphasizing the need for accurate diagnosis and appropriate management strategies. The study presents an intriguing case of a 50-year-old man with a large de novo primary ductal adenocarcinoma of the lacrimal gland, initially misdiagnosed as a meningeal solitary fibrous tumor due to its atypical clinical presentation of "down and out" proptosis. The case underscores the importance of histopathology to achieve a correct diagnosis and guide management decisions. Despite aggressive treatment approaches, the prognosis of primary ductal adenocarcinoma patients remains grim due to its aggressive behavior and tendency for recurrence and metastasis. The present case study emphasizes that a differential of primary ductal adenocarcinoma should be considered despite the presence of anomalous clinical and radiological presentation.

揭开谜团:巨大的原发性泪腺低分化导管腺癌,具有侵袭性特征。病例报告及文献复习。
摘要原发性泪腺导管腺癌(PDA)是一种罕见的起源于导管上皮细胞的侵袭性恶性肿瘤。其罕见性和多样化的临床表现构成了重大的诊断挑战,强调需要准确的诊断和适当的管理策略。本研究报告了一个有趣的病例,一名50岁的男性患有巨大的原发性泪腺导管腺癌,由于其不典型的临床表现为“彻头彻尾”的突出,最初被误诊为脑膜孤立性纤维性肿瘤。该病例强调了组织病理学对实现正确诊断和指导管理决策的重要性。尽管采用积极的治疗方法,但原发性导管腺癌患者的预后仍然严峻,因为其具有侵袭性和复发转移的倾向。本病例研究强调,尽管存在异常的临床和放射表现,原发性导管腺癌的鉴别应予以考虑。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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