Spinal cord injury and male infertility: Effect of the inflammasome proteins on semen quality.

IF 1.8 4区医学 Q3 CLINICAL NEUROLOGY

Journal of Spinal Cord Medicine Pub Date : 2025-04-01 DOI:10.1080/10790268.2025.2472095

Karla Pacheco de Melo, Giovana Salla Siqueira de Souza, Emad Ibrahim, Charles M Lynne, Nancy L Brackett, Ricardo Pimenta Bertolla, Mariana Camargo

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引用次数: 0

Abstract

Objective: To evaluate seminal plasma levels of Biglycan, Cystatin-S, β-2 microglobulin and inflammasome proteins and to investigate their role in seminal toxicity in men with spinal cord injury (SCI).

Study design: cross-sectional study.

Setting: Miami Project to Cure Paralysis - University of Miami / Miller School of Medicine and Federal University of Sao Paulo.

Participants: Eight men with spinal cord injury and eight men without spinal cord injury (controls).

Intervention: none. Outcome measures: semen analysis as per WHO 2010 guidelines; seminal plasma ELISA for IL-1β, IL-18 and caspase-1; and Western blotting for Biglycan, β-2microglobulin and Cystatin-S proteins.

Results: Proteins from the inflammasome complex are elevated in men with SCI, as previously described. In addition, β-2-microgobulin, Cystatin-S and two different isoforms of Byglican are elevated in men with SCI.

Conclusion: a different pathway to activate the inflammasome complex is present in men with spinal cord injury. This pathway can be a potential target for new interventions in the future.

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来源期刊

Journal of Spinal Cord Medicine 医学-临床神经学

CiteScore

4.20

自引率

5.90%

发文量

101

审稿时长

6-12 weeks

期刊介绍： For more than three decades, The Journal of Spinal Cord Medicine has reflected the evolution of the field of spinal cord medicine. From its inception as a newsletter for physicians striving to provide the best of care, JSCM has matured into an international journal that serves professionals from all disciplines—medicine, nursing, therapy, engineering, psychology and social work.