Association between low serum testosterone level and severe asthma among elderly women.

IF 6.2 2区医学 Q1 ALLERGY

Allergology International Pub Date : 2025-03-29 DOI:10.1016/j.alit.2024.12.008

Kai Ryu, Yuma Fukutomi, Eiji Nakatani, Yosuke Kamide, Kiyoshi Sekiya, Takeo Ishikawa, Takanori Numata, Jun Araya, Kazuyoshi Kuwano, Masami Taniguchi, Hiroaki Masuzaki

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引用次数: 0

Abstract

Background: Elderly asthma has distinct pathophysiologic and phenotypic characteristics compared with asthma in younger patients. However, a potential relationship between sex hormones and the severity of asthma remains unknown in the elderly population. The aim of the present study was to elucidate the relationship between the level of circulating free testosterone and severity of asthma among Japanese with elderly asthma.

Methods: The level of free testosterone was measured using sera from elderly patients with asthma aged ≥60 years (n = 192), and its association with the severity of asthma was examined after stratification by sex.

Results: Based on previous literature and our preliminary analysis showing that current oral corticosteroid (OCS) use might be a risk factor for a lower free testosterone level regardless of severity of asthma, analyzed patients were limited to those who were not currently using OCS (n = 164). Regarding elderly men who were not currently using OCS (n = 62), there was no significant association between free testosterone level and severity of asthma. However, in female counterparts (n = 102), a low free testosterone level was significantly associated with severe asthma even after adjustment for age (p for trend, 0.03).

Conclusions: The present study showed a significant association between the serum free testosterone level and severity of asthma among elderly women who were not currently using OCS. Although the causal relationship is unclear, this finding may provide a clue to understand the sex difference in the mechanisms of severe asthma in elderly populations.

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老年妇女低血清睾酮水平与严重哮喘的关系

背景：与年轻患者相比，老年哮喘具有明显的病理生理和表型特征。然而，性激素与老年人哮喘严重程度之间的潜在关系尚不清楚。本研究旨在阐明日本老年哮喘患者循环游离睾酮水平与哮喘严重程度之间的关系。方法：使用年龄≥60岁的老年哮喘患者血清（n = 192）检测游离睾酮水平，并按性别分层后检测其与哮喘严重程度的相关性。结果：基于先前的文献和我们的初步分析显示，无论哮喘的严重程度如何，目前口服皮质类固醇（OCS）的使用可能是游离睾酮水平降低的一个危险因素，分析的患者仅限于目前未使用OCS的患者（n = 164）。对于目前未使用OCS的老年男性（n = 62），游离睾酮水平与哮喘严重程度之间无显著相关性。然而，在女性中（n = 102），低游离睾酮水平与严重哮喘显著相关，即使在年龄调整后也是如此（趋势p为0.03）。结论：本研究显示，在目前未使用OCS的老年妇女中，血清游离睾酮水平与哮喘严重程度之间存在显著相关性。虽然因果关系尚不清楚，但这一发现可能为了解老年人严重哮喘机制的性别差异提供了线索。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Allergology International ALLERGY-IMMUNOLOGY

CiteScore

12.60

自引率

5.90%

发文量

审稿时长

29 weeks

期刊介绍： Allergology International is the official journal of the Japanese Society of Allergology and publishes original papers dealing with the etiology, diagnosis and treatment of allergic and related diseases. Papers may include the study of methods of controlling allergic reactions, human and animal models of hypersensitivity and other aspects of basic and applied clinical allergy in its broadest sense. The Journal aims to encourage the international exchange of results and encourages authors from all countries to submit papers in the following three categories: Original Articles, Review Articles, and Letters to the Editor.