Does exercise training combined with blood flow restriction improve muscle mass, lower extremity function, and walking capacity in hemiplegic patients? A randomized clinical trial.

IF 2.2 4区 医学 Q1 REHABILITATION
Yali Feng, Fanglin Wen, Irfan Ahmad, Yuanyuan Chen, Wenwen Ye, Hang Jiang, Hao Li, Jinshan Dai, Le Li, Rui Hu, Can Teng, Ying Yin
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Abstract

Background: Blood flow restriction creates a state with increased motor function that permits treatment modalities to induce muscle hypertrophy. Blood flow-restricted exercise training (BFRET) may induce motor learning and boost the facilitatory effect of exercise training (ET).

Objective: This study investigated the effects of BFRET on post-stroke hemi paretic lower extremity function and walking capacity recovery.

Methodology: This randomized clinical trial was conducted from September 2021 to October 2022 at the Department of Rehabilitation Medicine of the Second Affiliated Hospital of Chongqing Medical University in China. Participants were randomized 1:1 to BFRET or ET, each involving 30 minutes of training twice per day for 4 weeks.

Main outcomes measures: The main outcomes were manual muscle testing (MMT) and Fugl-Meyer assessment scale-lower extremity (FMA-LE), the timed up and go test (TUGT), Outcomes were assessed by blinded raters after 4 weeks of training.

Results: 40 participants mean [SD] age 48.79[12.58] years, 30 males [75%], 20 were randomized to BFRET and 20 to ET. The mean (SD) time since stroke was 2.5 (1.3) years. The MMT scores showed greater strength by within-group comparisons and superior changes in hip flexion and plantar flexion in the BFRET group.

Conclusions: BFRET is superior to ET alone in enhancing muscle mass and strength in the lower extremities. BFRET may improve the function of the lower extremities through physiological adaptations for muscle hypertrophy.

Registration: URL: https://www.clinicaltrials.gov; Unique identifier: ChiCTR2100050206.

运动训练结合血流限制是否能改善偏瘫患者的肌肉质量、下肢功能和行走能力?一项随机临床试验。
背景:血流限制产生运动功能增加的状态,允许治疗方式诱导肌肉肥大。血流受限运动训练(BFRET)可以诱导运动学习,增强运动训练(ET)的促进作用。目的:探讨BFRET对脑卒中后半麻痹性下肢功能和行走能力恢复的影响。方法:该随机临床试验于2021年9月至2022年10月在中国重庆医科大学第二附属医院康复医学科进行。参与者以1:1的比例随机分配到BFRET或ET组,每个组每天两次,每次30分钟,持续4周。主要观察指标:主要观察指标为手工肌肉测试(MMT)、Fugl-Meyer下肢评估量表(FMA-LE)、计时起跑测试(TUGT),训练4周后采用盲法评分。结果:40名参与者平均[SD]年龄48.79[12.58]岁,30名男性[75%],20名随机分为BFRET组,20名随机分为ET组。卒中后平均(SD)时间为2.5(1.3)年。通过组内比较,MMT评分显示出更大的强度,BFRET组髋屈曲和足底屈曲的变化也更好。结论:BFRET在增强下肢肌肉质量和力量方面优于单独ET。BFRET可能通过对肌肉肥大的生理适应来改善下肢功能。注册:网址:https://www.clinicaltrials.gov;唯一标识符:ChiCTR2100050206。
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来源期刊
Topics in Stroke Rehabilitation
Topics in Stroke Rehabilitation 医学-康复医学
CiteScore
5.10
自引率
4.50%
发文量
57
审稿时长
6-12 weeks
期刊介绍: Topics in Stroke Rehabilitation is the leading journal devoted to the study and dissemination of interdisciplinary, evidence-based, clinical information related to stroke rehabilitation. The journal’s scope covers physical medicine and rehabilitation, neurology, neurorehabilitation, neural engineering and therapeutics, neuropsychology and cognition, optimization of the rehabilitation system, robotics and biomechanics, pain management, nursing, physical therapy, cardiopulmonary fitness, mobility, occupational therapy, speech pathology and communication. There is a particular focus on stroke recovery, improving rehabilitation outcomes, quality of life, activities of daily living, motor control, family and care givers, and community issues. The journal reviews and reports clinical practices, clinical trials, state-of-the-art concepts, and new developments in stroke research and patient care. Both primary research papers, reviews of existing literature, and invited editorials, are included. Sharply-focused, single-issue topics, and the latest in clinical research, provide in-depth knowledge.
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