Trajectory of change in symptom patterns among patients undergoing surgery for oesophageal cancer: a prospective longitudinal study using latent transition analysis.

IF 2.8 3区医学 Q2 HEALTH CARE SCIENCES & SERVICES

Supportive Care in Cancer Pub Date : 2025-03-31 DOI:10.1007/s00520-025-09375-z

Xuanxuan Ma, Mengmeng Yuan, Lijun Wu, Shaoxue Li, Jie He, Di Wang, Shuwen Li

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引用次数: 0

Abstract

Purpose: Patients with oesophageal cancer may experience a heavy burden of postoperative symptoms. There is insufficient evidence to fully explain the role of symptom clusters in the trajectory of cancer care for patients with oesophagectomy. The aim of this study was to identify the change trajectory of individual symptoms after surgery.

Methods: A prospective longitudinal study was conducted to investigate patients' experience of symptoms at four time points after surgery. Latent profile analysis was used to identify patients' unique postoperative symptom experiences, and latent transition analysis was used to identify changes in patient symptom patterns across time points.

Results: Among the 398 patients, there were three symptom groups: the "persistent fatigue group", "fluctuating physical symptoms group", and "high symptoms group". Over time, the "persistent fatigue group" had a greater than 70% probability of remaining in this group, while the "fluctuating physical symptoms group" and "high symptoms group" had a large change in transition. Anastomotic site, primary caregiver, and cancer stage were found to predict the pattern of transition between symptom groups.

Conclusions: Patients' experience of symptoms changes over time, and it is important to target interventions based on the trajectory of symptoms to improve symptom management in oesophageal cancer patients.

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食道癌手术患者症状模式的变化轨迹：利用潜在转变分析法进行的前瞻性纵向研究。

目的：食管癌患者术后症状负担较重。没有足够的证据来充分解释症状群在食管癌切除术患者癌症治疗轨迹中的作用。本研究的目的是确定手术后个体症状的变化轨迹。方法：采用前瞻性纵向研究，调查患者术后四个时间点的症状经历。潜伏剖面分析用于识别患者术后独特的症状体验，潜伏过渡分析用于识别患者症状模式在不同时间点上的变化。结果：398例患者中存在“持续性疲劳组”、“波动躯体症状组”和“高症状组”三个症状组。随着时间的推移，“持续性疲劳组”留在该组的概率大于70%，而“波动身体症状组”和“高症状组”的过渡变化较大。发现吻合口位置、主要照顾者和癌症分期预测症状组之间的转移模式。结论：患者的症状经历会随着时间的推移而改变，根据症状的发展轨迹进行有针对性的干预对于改善食管癌患者的症状管理非常重要。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Supportive Care in Cancer 医学-康复医学

CiteScore

5.70

自引率

9.70%

发文量

751

审稿时长

3 months

期刊介绍： Supportive Care in Cancer provides members of the Multinational Association of Supportive Care in Cancer (MASCC) and all other interested individuals, groups and institutions with the most recent scientific and social information on all aspects of supportive care in cancer patients. It covers primarily medical, technical and surgical topics concerning supportive therapy and care which may supplement or substitute basic cancer treatment at all stages of the disease. Nursing, rehabilitative, psychosocial and spiritual issues of support are also included.