Use of non-qualifying umbilical cord blood units to support research and quality assurance by the Canadian Blood Services Cord Blood Bank.

IF 2.5 3区医学 Q2 HEMATOLOGY

Transfusion Pub Date : 2025-03-31 DOI:10.1111/trf.18231

David S Allan, Matthew D Seftel, An Duong, Harinad Maganti, Kathy Ganz, Nicholas Dibdin, Meagan Green, Jennifer Laycock, Subh Sarkar, Charlene Ropp, Tanya Petraszko, Jelena L Holovati

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引用次数: 0

Abstract

Background: Umbilical cord blood units collected by Canadian Blood Services for public banking at selected collection hospitals may not meet stringent criteria for release to the bank's inventory and can be used to support research. The Cord Blood for Research Program (CB4RP) was established when the CBS bank was established, but the breadth of research activity supported by the CB4RP has not been previously described.

Methods: Records of projects and units requested to support research were reviewed and summarized from September 2014 to October 2024.

Results: A total of 34 projects have been supported by the CB4RP, with a total of 2901 units requested (85.4 units per project, range 6-540). To date, 1505 fresh units and 28 frozen units have been shipped to researchers. Areas of research supported by the CB4RP include hematopoietic cell transplant research, regenerative therapy, immunology research, cancer research, transfusion research, and other categories.

Conclusion: Distributing non-qualifying cord blood units for research leverages the public investments implicated in establishing the CBS CBB and supports the development of expertise across a broad range of research areas.

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背景：加拿大血液服务机构在选定的采集医院采集的脐带血单位可能不符合严格的入库标准，但可用于支持研究。研究用脐带血计划（CB4RP）是在加拿大血液服务机构库成立时设立的，但以前没有对CB4RP所支持的研究活动的广度进行过描述：方法：回顾并总结了 2014 年 9 月至 2024 年 10 月期间申请支持研究的项目和单位的记录：CB4RP 共支持了 34 个项目，共申请了 2901 个单位（每个项目 85.4 个单位，范围为 6-540 个单位）。迄今为止，已向研究人员运送了 1505 个新鲜单位和 28 个冷冻单位。CB4RP 支持的研究领域包括造血细胞移植研究、再生疗法、免疫学研究、癌症研究、输血研究和其他类别：将不符合条件的脐带血单位用于研究，充分利用了建立 CBB 的公共投资，并支持了广泛研究领域的专业技术发展。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Transfusion 医学-血液学

CiteScore

4.70

自引率

20.70%

发文量

426

审稿时长

1 months

期刊介绍： TRANSFUSION is the foremost publication in the world for new information regarding transfusion medicine. Written by and for members of AABB and other health-care workers, TRANSFUSION reports on the latest technical advances, discusses opposing viewpoints regarding controversial issues, and presents key conference proceedings. In addition to blood banking and transfusion medicine topics, TRANSFUSION presents submissions concerning patient blood management, tissue transplantation and hematopoietic, cellular, and gene therapies.