Evidence Showing Three Layers of Reconstructed Tympanic Membrane After Second Regenerative Treatment.

IF 1.9 3区 医学 Q3 CLINICAL NEUROLOGY
Hiroshi Hidaka, Tomofumi Sakagami, Yuri Noda, Akihiro Shimamura, Hiroshi Iwai
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引用次数: 0

Abstract

Objective: To describe the case of a patient who twice underwent recently developed regenerative treatment for tympanic membrane perforation (RT-TMP), achieving successful regeneration of the TM consisting of three layers (epidermis, lamina propria, and mucosa) on pathological analyses of the regenerated part.

Study design: Clinical capsule report.

Patient: A 48-year-old woman with right chronic otitis media, showing a large TMP covering 80% of the total TM.

Interventions: After the initial RT-TMP, the patient had a residual posterior TMP affecting 25% of the TM. At the second procedure, a portion of the previously regenerated TM was harvested for pathological analysis.

Results: Pathological analysis of the surgical specimen showed that the regenerated TM tissue coandnsisted of three parts: outer epidermal, intermediate, and mucosal layers.

Conclusion: By applying a recently developed RT-TMP, this report describes the first human study confirming the regeneration of the TM consisting of three layers (epidermis, lamina propria, and mucosa) on pathological analyses of the regenerated part at the second RT-TMP. This is a major step toward the goal of TM regeneration that recapitulates the structural properties of the native TM.

证据显示二次再生治疗后鼓膜重建三层。
目的:描述一名患者两次接受近期发展的鼓膜穿孔再生治疗(RT-TMP)的病例,通过对再生部分的病理分析,成功地再生了由三层(表皮、固有层和粘膜)组成的鼓膜穿孔。研究设计:临床胶囊报告。患者:48岁女性,右侧慢性中耳炎,TMP较大,占总TM的80%。干预措施:在最初的RT-TMP治疗后,患者后侧残留的TMP影响了25%的TM。在第二次手术中,收集一部分先前再生的TM用于病理分析。结果:手术标本病理分析显示,再生的TM组织由外表皮、中间层和粘膜三部分组成。结论:本文采用最新开发的RT-TMP,首次在人体研究中证实了由三层(表皮、固有层和粘膜)组成的TM的再生,并对再生部分进行了第二次RT-TMP的病理分析。这是向TM再生目标迈出的重要一步,再现了原生TM的结构特性。
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来源期刊
Otology & Neurotology
Otology & Neurotology 医学-耳鼻喉科学
CiteScore
3.80
自引率
14.30%
发文量
509
审稿时长
3-6 weeks
期刊介绍: ​​​​​Otology & Neurotology publishes original articles relating to both clinical and basic science aspects of otology, neurotology, and cranial base surgery. As the foremost journal in its field, it has become the favored place for publishing the best of new science relating to the human ear and its diseases. The broadly international character of its contributing authors, editorial board, and readership provides the Journal its decidedly global perspective.
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