The Afterglow Inventory (AGI): Validation of a new instrument for measuring subacute effects of classic serotonergic psychedelics.

IF 4.5 3区 医学 Q1 CLINICAL NEUROLOGY
Tomislav Majić, Timo Torsten Schmidt, Anna Gröticke, Peter Gasser, William A Richards, Thomas G Riemer, Ricarda Evens
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引用次数: 0

Abstract

Background: Classic psychedelics such as psilocybin and lysergic acid diethylamide are anecdotally associated with the phenomenon of "psychedelic afterglow," a set of predominantly pleasant, temporary psychological effects reported after the acute effects have subsided. Since post-acute effects are crucial for the therapeutic use of psychedelics, an instrument to systematically assess subacute "afterglow" effects is needed.

Aims: To create and validate a questionnaire to quantify the subacute "afterglow" effects of psychedelics.

Methods: An international online survey was conducted in English and German. Participants who had consumed a psychedelic (N = 1323) or another non-psychedelic substance (control group, N = 157) within the past 4 weeks were included. An initial list of 97 items was progressively reduced to 24 items.

Results: A 5-factor structure best fit the data and showed high internal consistency. The factors included (1) vitality, (2) transpersonal aspects, (3) inspiration/creativity, (4) interpersonal relationships, and (5) relationship to nature. The final 24-item version of the Afterglow Inventory (AGI) effectively differentiated between the psychedelic group and the control group. The overall AGI score positively correlated with the intensity (r = 0.165; p < 0.001) and positive valence (r = 0.251; p < 0.001) of the acute psychedelic effects.

Conclusions: The AGI is a novel scale for quantifying positive subacute ("afterglow") effects of psychedelics. The use of the AGI could lead to a better understanding of the interplay between acute, subacute, and long-term effects of psychedelics. Insights could also be gained into how different substances, dosages, and extra-pharmacological factors, such as psychotherapy, might influence outcomes.

余辉量表(AGI):一种用于测量经典色氨酸致幻剂亚急性效应的新仪器的验证。
背景:经典的迷幻药,如裸盖菇素和麦角酸二乙胺,据说与“迷幻余辉”现象有关,这是一组在急性效应消退后主要令人愉快的暂时心理效应。由于急性后效应对致幻剂的治疗用途至关重要,因此需要一种系统评估亚急性“余辉”效应的仪器。目的:制作并验证一份问卷来量化迷幻药的亚急性“余辉”效应。方法:采用英语和德语进行国际在线调查。其中包括在过去4周内服用过致幻剂(N = 1323)或其他非致幻剂(N = 157)的参与者。最初的97项清单逐渐减少到24项。结果:5因子结构与数据拟合最佳,具有较高的内部一致性。这些因素包括(1)活力,(2)超个人方面,(3)灵感/创造力,(4)人际关系,(5)与自然的关系。余辉量表(AGI)的最后24项版本有效地区分了迷幻组和对照组。AGI总分与强度呈正相关(r = 0.165;p r = 0.251;结论:AGI是一种量化迷幻药阳性亚急性(“余辉”)效应的新量表。AGI的使用可以更好地理解致幻剂的急性、亚急性和长期效应之间的相互作用。还可以深入了解不同的物质、剂量和药物外因素(如心理治疗)如何影响结果。
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来源期刊
Journal of Psychopharmacology
Journal of Psychopharmacology 医学-精神病学
CiteScore
8.60
自引率
4.90%
发文量
126
审稿时长
3-8 weeks
期刊介绍: The Journal of Psychopharmacology is a fully peer-reviewed, international journal that publishes original research and review articles on preclinical and clinical aspects of psychopharmacology. The journal provides an essential forum for researchers and practicing clinicians on the effects of drugs on animal and human behavior, and the mechanisms underlying these effects. The Journal of Psychopharmacology is truly international in scope and readership.
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