A Fluorescent Probe Based on the Anti-Inflammatory Drug Benzydamine Hydrochloride for the Detection of Fe³⁺ Ions.

IF 2.6 4区化学 Q2 BIOCHEMICAL RESEARCH METHODS

Journal of Fluorescence Pub Date : 2025-03-31 DOI:10.1007/s10895-025-04284-0

Huiqin Wu, Zhimei Wang, Bo Li, Qing Chen

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引用次数: 0

Abstract

The detection of Fe³⁺ by benzydamine hydrochloride (BNZ) and its mechanism were studied by UV, fluorescence, infrared, and ¹H NMR spectroscopy. The results showed that BNZ could be used as a fluorescence probe to selectively identify Fe³⁺. Recognition results from coordination of Fe³⁺ by BNZ that leads to fluorescence quenching by electron transfer. A 1:1 complex is formed between BNZ and Fe³⁺ with a binding constant of 3.619 × 10⁴ M^- 1. The fluorescence intensity of BNZ was linearly correlated with the concentration of Fe³⁺ from 3.0 × 10^- 6 to 2.3 × 10^- 4 M, the detection limit was as low as 1.24 × 10^- 7 M, and the recovery rate of Fe³⁺ detected in tap water was 96-98%, which could enable quantitative detection and monitoring of Fe³⁺ in environmental systems, and the method is simple, accurate, low detection limit, and can detect Fe³⁺ quickly, selectively, and sensitively.

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来源期刊

Journal of Fluorescence 化学-分析化学

CiteScore

4.60

自引率

7.40%

发文量

203

审稿时长

5.4 months

期刊介绍： Journal of Fluorescence is an international forum for the publication of peer-reviewed original articles that advance the practice of this established spectroscopic technique. Topics covered include advances in theory/and or data analysis, studies of the photophysics of aromatic molecules, solvent, and environmental effects, development of stationary or time-resolved measurements, advances in fluorescence microscopy, imaging, photobleaching/recovery measurements, and/or phosphorescence for studies of cell biology, chemical biology and the advanced uses of fluorescence in flow cytometry/analysis, immunology, high throughput screening/drug discovery, DNA sequencing/arrays, genomics and proteomics. Typical applications might include studies of macromolecular dynamics and conformation, intracellular chemistry, and gene expression. The journal also publishes papers that describe the synthesis and characterization of new fluorophores, particularly those displaying unique sensitivities and/or optical properties. In addition to original articles, the Journal also publishes reviews, rapid communications, short communications, letters to the editor, topical news articles, and technical and design notes.