Systemic inflammation mediates the association between dietary inflammation index and incident anxiety and depression in UK Biobank.

IF 4.9 2区医学 Q1 CLINICAL NEUROLOGY

Journal of affective disorders Pub Date : 2025-03-28 DOI:10.1016/j.jad.2025.03.101

Yizhao Zhou, Chengcheng Zhang, Jingya Li, Ying Zheng, Shuiyuan Xiao

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引用次数: 0

Abstract

Background: Evidence on whether systemic inflammation mediates the association between diet and depression and anxiety is lacking.

Methods: We analyzed 55,799 participants from the UK Biobank, assessing dietary inflammatory index (DII) based on 3 days' 24-hour dietary recall. Systemic inflammation was represented by systemic immune-inflammation index (SII) and systemic inflammation response index (SIRI). Incident depression and anxiety were ascertained through linkage to hospital records, and Cox proportional hazard regression models evaluated the associations, with mediation analysis performed for systemic inflammation.

Results: DII ranged from -6.87 to 4.88 with a median of -0.67. After a median follow-up time of 9.12 years, 1409 were diagnosed with depression and 1806 with anxiety. Higher DII level is associated with the incident risk of depression (HR_Q4vsQ1 = 1.20, 1.09-1.32, P < 0.001) and anxiety (HR_Q4vsQ1 = 1.10, 1.00-1.21, P < 0.001). SIRI and SII respectively mediate 4.12 % (95 % CI = 1.30 %-23.3 %, P < 0.001) and 4.43 % (95 % CI = 1.89 %-43.75 %, P < 0.001) of the association between DII and depression incidence. As for anxiety, SIRI mediated 8.27 % (95 % CI = 1.44 %-15.31 %, P < 0.001) and SII mediated 4.19 % (95 % CI = 1.58 %-11.47 %, P < 0.001), respectively.

Limitations: The potential coexistence of anxiety and depression with other psychiatric disorders and limitations in data on changes in DII and inflammation markers over time may bias the findings. The study's generalization is constrained by the demographic of participants.

Conclusion: Our findings suggest that DII is positively associated with depression and anxiety, which may be mediated by SII/SIRI.

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来源期刊

Journal of affective disorders 医学-精神病学

CiteScore

10.90

自引率

6.10%

发文量

1319

审稿时长

9.3 weeks

期刊介绍： The Journal of Affective Disorders publishes papers concerned with affective disorders in the widest sense: depression, mania, mood spectrum, emotions and personality, anxiety and stress. It is interdisciplinary and aims to bring together different approaches for a diverse readership. Top quality papers will be accepted dealing with any aspect of affective disorders, including neuroimaging, cognitive neurosciences, genetics, molecular biology, experimental and clinical neurosciences, pharmacology, neuroimmunoendocrinology, intervention and treatment trials.