FORMATION OF ARTIFICIAL BURNS IN WISTAR RATS TO EVALUATE THE EFFECTS OF DIFFERENT DRUGS.

Q4 Medicine
Georgian medical news Pub Date : 2025-01-01
D Kubaevskaya, P Olennikov, S Ishmaev, E Balakireva, D Labazanov, S Boguslavets, V Beskadarov, S Zhidkov, I Budeykina, D Komolov
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引用次数: 0

Abstract

Burns are a common problem faced by mankind, which in turn affects function and quality of life. Over the centuries, many anti-burn drugs have been developed. In this article the effect of different preparations: Agrosulfan-anti-burn preparation, Shostakovsky's Balsam-anti-burn preparation, Alfazox-esophagoprotector, on artificially formed burns with the help of electrocoagulator on Wistar rats is considered. The rats were kept in standard vivarium conditions in cages under natural light regime and on normal diet with free access to water and food. Comparison of preparations was carried out, the indication of which is treatment of burns. But in comparison with other preparations «Alfazox» is an esophagoprotector, on the basis of its properties (promotes healing of gastric mucosa erosions) and composition (Chondroitin sulfate + hyaluronic acid + poloxamer 407), this preparation can be prescribed for burns off-label. By means of daily measurement of the burn surface area and estimation of tissue repair rate. preparations showed the following results: Agrosulfan - complete epithelization of the wound occurred on the 11th day, showed the best result, «Alfazox» - 13 days, belonging to esophagoprotectors, in contrast to the control group (16 days), which makes it possible to prescribe it off-label. The period of complete epithelialisation of Shostakovsky's Balsam was 14 days. The terms of the control group were 16 days.

不同药物对wistar大鼠人工烧伤形成的影响。
烧伤是人类面临的普遍问题,严重影响人体的功能和生活质量。几个世纪以来,人们开发了许多抗烧伤药物。本文研究了不同制剂:Agrosulfan-anti-burn制剂、肖斯塔科夫斯基香脂-anti-burn制剂、alfazox -食管保护剂对电凝剂辅助Wistar大鼠人工烧伤的影响。大鼠饲养在标准的笼内,自然光条件下,正常饮食,自由饮水和食物。进行了制剂比较,其中适应症是治疗烧伤。但与其他制剂相比,“Alfazox”是一种食管保护剂,基于其特性(促进胃粘膜糜烂愈合)和成分(硫酸软骨素+透明质酸+ poloxam407),该制剂可用于标签外烧伤。通过每日烧伤面积的测量和组织修复率的估计。阿法唑(Alfazox) - 13天,属于食管保护剂,与对照组(16天)相比,这使得它可以在标签外开处方。肖斯塔可夫斯基的《香脂》完全上皮化时间为14天。对照组疗程为16 d。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Georgian medical news
Georgian medical news Medicine-Medicine (all)
CiteScore
0.60
自引率
0.00%
发文量
207
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