Xueshan Li, Min Liu, Bo Liu, Heng Yue, Xiangjuan Cheng, Hugejiletu Bao
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引用次数: 0
Abstract
Background and objective: The psychological mechanisms that make Conditioned Pain Modulation (CPM) an effective non-pharmacological intervention are still not fully understood. Expectancy is believed to be a critical psychological factor affecting CPM effects, but its specific role has yet to be fully clarified. This study aims to explore the relationship between expectancy and CPM while providing physiological evidence using functional near-infrared spectroscopy (fNIRS).
Method: A standardized CPM induction paradigm was implemented, with verbal guidance used to induce expectancy. The Numeric Rating Scale (NRS) assessed the intensity of the test stimulus (TS), while an 11-point scale evaluated participants' attentional focus on the TS and the effect of expectancy. fNIRS was employed to monitor changes in prefrontal cortex (PFC) activity.
Results: Expectancy significantly amplified the CPM effect (p = 0.036) while markedly reducing attention to the experimental stimulus (p = 0.004). fNIRS findings indicated significant reductions in activity within the left frontal eye field, left dorsolateral prefrontal cortex, and left frontal pole regions. In the post-test, the control group demonstrated significantly higher cortical activity in the right frontal pole region compared to the expectancy group (p < 0.05). Within the expectancy group, bilateral frontal pole cortical activity was significantly lower in the post-test compared to the pre-test (p < 0.05).
Conclusion: Expectancy represents a key psychological mechanism underlying the CPM effect, potentially modulating its magnitude through attention regulation and accompanied by a reduction in oxygenated hemoglobin activity in the frontal pole region and introduced the Expectancy-Attention-CPM Modulation Model (ECAM).
期刊介绍：
Frontiers in Psychology is the largest journal in its field, publishing rigorously peer-reviewed research across the psychological sciences, from clinical research to cognitive science, from perception to consciousness, from imaging studies to human factors, and from animal cognition to social psychology. Field Chief Editor Axel Cleeremans at the Free University of Brussels is supported by an outstanding Editorial Board of international researchers. This multidisciplinary open-access journal is at the forefront of disseminating and communicating scientific knowledge and impactful discoveries to researchers, academics, clinicians and the public worldwide. The journal publishes the best research across the entire field of psychology. Today, psychological science is becoming increasingly important at all levels of society, from the treatment of clinical disorders to our basic understanding of how the mind works. It is highly interdisciplinary, borrowing questions from philosophy, methods from neuroscience and insights from clinical practice - all in the goal of furthering our grasp of human nature and society, as well as our ability to develop new intervention methods.
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