The effect of beinaglutide as an glucagon-like peptide-1 receptor agonists on cardiometabolic factors: a systematic review and meta-analysis.

IF 3.4 3区医学 Q2 ENDOCRINOLOGY & METABOLISM

Diabetology & Metabolic Syndrome Pub Date : 2025-04-01 DOI:10.1186/s13098-025-01633-8

Yan Xu, Periyannan Velu, Li Hu, Nathalia Sernizon Guimarães

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引用次数: 0

Abstract

Background: Considering the important role of cardiometabolic risk factors in different societies on increasing the burden of non-communicable diseases, in this study we will investigate the possible effects of Beinaglutide as an glucagon-like peptide-1 receptor agonists (GLP-1RAs) on these risk factors.

Methods: In order to identify all randomized controlled trials that investigated the effects of Beinaglutide on cardiometabolic factors, a systematic search was conducted in the original databases using predefined keywords until July 2024. The pooled weighted mean difference and 95% confidence intervals were computed using the random-effects model.

Results: A quantitative meta-analysis results from 7 studies with 872 participants showed that Beinaglutide has a significant lowering effect on weight (WMD: -3.74 kg; 95% CI: -5.03, -2.45), body mass index (BMI) (WMD:-1.64 kg/m²; 95% CI: -2.10, -1.17), waist circumference (WC) (WMD: -3.19 cm; 95% CI: -4.65 to -1.73), triglycerid (TG) levels (WMD: -0.14 mmol/l with; 95% CI: -0.25, -0.04), and systolic blood pressure (SBP) (WMD: -1.76 mm/Hg; 95% CI: -2.61, -0.91). Furthermore, the results obtain from subgroup analysis showed a greater effect of Beinaglutide on the reduction of weight and TG during the intervention of more than 12 weeks. In addition, body weight loss was greater in doses less than 0.4 mg compared to doses greater than or equal to 0.4 mg.

Conclusions: The results of this meta-analysis show that Beinaglutide is effective in reducing factors related to obesity, TG as wll as SBP, especially with longer interventions and lower doses.

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来源期刊

Diabetology & Metabolic Syndrome ENDOCRINOLOGY & METABOLISM-

CiteScore

6.20

自引率

0.00%

发文量

170

审稿时长

7.5 months

期刊介绍： Diabetology & Metabolic Syndrome publishes articles on all aspects of the pathophysiology of diabetes and metabolic syndrome. By publishing original material exploring any area of laboratory, animal or clinical research into diabetes and metabolic syndrome, the journal offers a high-visibility forum for new insights and discussions into the issues of importance to the relevant community.