{"title":"The ABC of transplant: ALAD, BLAD, and CLAD: definition and significance.","authors":"Geert M Verleden, Saskia Bos","doi":"10.1097/MCP.0000000000001170","DOIUrl":null,"url":null,"abstract":"<p><strong>Purpose of review: </strong>Chronic lung allograft dysfunction (CLAD) is a recognized complication after lung transplantation, with a clear definition, although some pitfalls in phenotyping still exist. Recently, new terminologies, such as acute lung allograft dysfunction (ALAD) and baseline lung allograft dysfunction (BLAD) were introduced, but their definitions and real significance are not yet fully established.</p><p><strong>Recent findings: </strong>Based on the existing literature and ongoing discussions within two expert groups of the Advanced Lung Failure & Transplantation Interdisciplinary Network (ALFTx IDN) of the International Society for Heart and Lung Transplantation (ISHLT), we will describe current definitions, prevalence and outcome of these rather new entities, keeping in mind that a lot of uncertainties still exist.</p><p><strong>Summary: </strong>ALAD and BLAD will be defined, and the currently accepted outcome of these conditions will be summarized. Existing pitfalls in the phenotyping of CLAD will also be discussed.</p>","PeriodicalId":11090,"journal":{"name":"Current Opinion in Pulmonary Medicine","volume":" ","pages":"397-403"},"PeriodicalIF":2.8000,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Current Opinion in Pulmonary Medicine","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1097/MCP.0000000000001170","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/5/8 0:00:00","PubModel":"Epub","JCR":"Q2","JCRName":"RESPIRATORY SYSTEM","Score":null,"Total":0}
引用次数: 0
Abstract
Purpose of review: Chronic lung allograft dysfunction (CLAD) is a recognized complication after lung transplantation, with a clear definition, although some pitfalls in phenotyping still exist. Recently, new terminologies, such as acute lung allograft dysfunction (ALAD) and baseline lung allograft dysfunction (BLAD) were introduced, but their definitions and real significance are not yet fully established.
Recent findings: Based on the existing literature and ongoing discussions within two expert groups of the Advanced Lung Failure & Transplantation Interdisciplinary Network (ALFTx IDN) of the International Society for Heart and Lung Transplantation (ISHLT), we will describe current definitions, prevalence and outcome of these rather new entities, keeping in mind that a lot of uncertainties still exist.
Summary: ALAD and BLAD will be defined, and the currently accepted outcome of these conditions will be summarized. Existing pitfalls in the phenotyping of CLAD will also be discussed.
期刊介绍：
Current Opinion in Pulmonary Medicine is a highly regarded journal offering insightful editorials and on-the-mark invited reviews, covering key subjects such as asthma; cystic fibrosis; infectious diseases; diseases of the pleura; and sleep and respiratory neurobiology. Published bimonthly, each issue of Current Opinion in Pulmonary Medicine introduces world renowned guest editors and internationally recognized academics within the pulmonary field, delivering a widespread selection of expert assessments on the latest developments from the most recent literature.
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