Correlation between pulmonary to systemic flow ratio and N-terminal Pro-B-type natriuretic peptide level in children with atrial septal defect.

IF 2.8 3区医学 Q2 CARDIAC & CARDIOVASCULAR SYSTEMS

Frontiers in Cardiovascular Medicine Pub Date : 2025-03-14 eCollection Date: 2025-01-01 DOI:10.3389/fcvm.2025.1522603

Li-Chin Liao, Yun-Yu Chen, Yun-Ching Fu, Hui-Chih Hung

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引用次数: 0

Abstract

Introduction: Atrial septal defect (ASD) increases pulmonary to systemic flow ratio (Q _p/Q _s) which is an important determinant factor for treatment. N-terminal pro-B-type natriuretic peptide (NT-proBNP) levels are correlated with volume overloading of the heart. This study aims to explore the relationship between Q _p/Q _s and NT-proBNP levels in children with ASD.

Materials and methods: Between January 2010 and December 2023, 464 patients under 20 years old with ASD who underwent cardiac catheterization and received NT-proBNP test were enrolled retrospectively. Baseline characteristics such as sex, body weight, and age were recorded. Q _p/Q _s was measured during standardized right heart catheterization according to Fick principle.

Results: A significant positive correlation existed between NT-proBNP and Q _p/Q _s (R = 0.507, P < 0.001), with an R ² of 0.258. The linear regression model indicates that a one-unit (pg/ml) increase in NT-proBNP corresponded to a 0.003-unit increase in Q _p/Q _s (P < 0.001). Patients with a Q _p/Q _s ratio ≥ 2 had significantly higher NT-proBNP levels than those with a ratio <2 (P < 0.001).

Conclustion: This study, the largest cohort to date, reveals the correlation between non-invasive NT-proBNP level and invasive Q _p/Q _s measurement in children with ASD.

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来源期刊

Frontiers in Cardiovascular Medicine Medicine-Cardiology and Cardiovascular Medicine

CiteScore

3.80

自引率

11.10%

发文量

3529

审稿时长

14 weeks

期刊介绍： Frontiers? Which frontiers? Where exactly are the frontiers of cardiovascular medicine? And who should be defining these frontiers? At Frontiers in Cardiovascular Medicine we believe it is worth being curious to foresee and explore beyond the current frontiers. In other words, we would like, through the articles published by our community journal Frontiers in Cardiovascular Medicine, to anticipate the future of cardiovascular medicine, and thus better prevent cardiovascular disorders and improve therapeutic options and outcomes of our patients.