Gonadal sex determination in vertebrates: rethinking established mechanisms.

IF 3.7 2区生物学 Q1 DEVELOPMENTAL BIOLOGY

Development Pub Date : 2025-03-15 Epub Date: 2025-03-31 DOI:10.1242/dev.204592

Dagmar Wilhelm, Aitana Perea-Gomez, Axel Newton, Marie-Christine Chaboissier

引用次数: 0

Abstract

Sex determination and differentiation are fundamental processes that are not only essential for fertility but also influence the development of many other organs, and hence, are important for species diversity and survival. In mammals, sex is determined by the inheritance of an X or a Y chromosome from the father. The Y chromosome harbours the testis-determining gene SRY, and it has long been thought that its absence is sufficient for ovarian development. Consequently, the ovarian pathway has been treated as a default pathway, in the sense that ovaries do not have or need a female-determining factor. Recently, a female-determining factor has been identified in mouse as the master regulator of ovarian development. Interestingly, this scenario was predicted as early as 1983. In this Review, we discuss the model predicted in 1983, how the mechanisms and genes currently known to be important for sex determination and differentiation in mammals have changed or supported this model, and finally, reflect on what these findings might mean for sex determination in other vertebrates.

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脊椎动物性腺性别决定：重新思考已建立的机制。

性别决定和分化是基本的过程，不仅是生育的必要条件，而且影响许多其他器官的发育，因此对物种多样性和生存很重要。在哺乳动物中，性别是由父亲遗传的X或Y染色体决定的。Y染色体含有睾丸决定基因SRY，长期以来人们一直认为，缺少该基因对卵巢发育是足够的。因此，卵巢途径被视为默认途径，在卵巢没有或不需要女性决定因素的意义上。最近，在小鼠中发现了一种雌性决定因子，它是卵巢发育的主要调节因子。有趣的是，这种情况早在1983年就被预测到了。在这篇综述中，我们讨论了1983年预测的模型，以及目前已知的哺乳动物性别决定和分化的重要机制和基因是如何改变或支持这一模型的，并反思了这些发现对其他脊椎动物性别决定的意义。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Development 生物-发育生物学

CiteScore

6.70

自引率

4.30%

发文量

433

审稿时长

3 months

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