Effect of novel IL-8 gene mutation on its protein structure and stability among ovarian cancer patients in Saudi Arabia.

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Bioinformation Pub Date : 2024-11-30 eCollection Date: 2024-01-01 DOI:10.6026/9732063002001671

Absarul Haque, Ghazanfar Ali Baig, Abdulelah Saleh Alshawli, Khalid Hussain Wali Sait, Hani S H Mohammed Ali, Hesham Khalid Hussain Sait, Fehmida Bibi, Peter Natesan Pushparaj, Mahmood Rasool, Muhammad Imran Naseer

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Abstract

Despite advancements in therapeutics, early diagnosis of ovarian cancer (OC) remains a challenge due to its asymptomatic progression and it is often diagnosed at an advanced stage. Interleukin-8 (IL-8), a pro-inflammatory chemokine with angiogenic activity, plays a pivotal role in inflammation and carcinogenesis. Therefore, it is of interest to investigate the association between IL-8 polymorphisms and OC risk. A novel non-synonymous SNP (nsSNP, c.193G>A; p.Glu65Leu) was identified in exon 2 of the IL-8 gene in 5 patients, 3 with stage III and 2 with stage II tumor. Structural analysis suggested that the p.Glu65Leu mutation alters the IL-8 protein conformation showing functional impairment. Thus, data shows that IL-8 c.193 G >A (Glu65Leu) polymorphism may contribute to tumor susceptibility. However, further studies are warranted to understand the role of IL-8 polymorphism in OC.

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沙特阿拉伯卵巢癌患者IL-8基因突变对其蛋白结构和稳定性的影响

尽管在治疗方面取得了进展，但卵巢癌（OC）的早期诊断仍然是一个挑战，因为卵巢癌的进展无症状，而且往往在晚期才被诊断出来。白细胞介素-8（IL-8）是一种具有血管生成活性的促炎症趋化因子，在炎症和癌变中起着关键作用。因此，研究 IL-8 多态性与卵巢癌风险之间的关系很有意义。在 5 例患者（3 例 III 期和 2 例 II 期肿瘤患者）的 IL-8 基因第 2 外显子中发现了一个新的非同义 SNP（nsSNP，c.193G>A；p.Glu65Leu）。结构分析表明，p.Glu65Leu 突变改变了 IL-8 蛋白的构象，显示出功能障碍。因此，数据显示 IL-8 c.193 G >A (Glu65Leu) 多态性可能导致肿瘤易感性。然而，要了解 IL-8 多态性在 OC 中的作用，还需要进一步的研究。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Bioinformation MATHEMATICAL & COMPUTATIONAL BIOLOGY-

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