Acquired FX Deficiency in Multiple Myeloma Without Concomitant Amyloidosis- A Rare Case Report.

Abstract

This case report presents a rare occurrence of acquired Factor X (FX) deficiency in a patient with Multiple myeloma (MM) without concomitant amyloidosis. The patient, a 64-year-old male with prior diagnosis of Smoldering MM, presented with abdominal pain and chronic bloody diarrhea and was diagnosed with severe FX deficiency. Despite initial suspicion of amyloidosis, subsequent investigations ruled out its presence. Treatment with anti-myeloma therapy and supportive measures resulted in the normalization of coagulation parameters. This case underscores the importance of considering acquired FX deficiency in Plasma Cell Dyscrasia patients presenting with coagulopathy.