‘EarlyAMDRate’: A grading instrument for OCT-based assessment of early lesions caused by age-related macular degeneration

IF 3 3区医学 Q1 OPHTHALMOLOGY

Acta Ophthalmologica Pub Date : 2025-03-30 DOI:10.1111/aos.17479

Marcus Wagner, Thomas Peschel, Carla J. Leutloff, Franziska G. Rauscher

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Abstract

Background and Objectives

Long before any signs of age-related macular degeneration (AMD) become clinically noticeable, the disease starts with accumulation of deposits of extracellular debris and formation of lesions within the outermost layers of the retina. For a reliable imaging of lesions in these early stages, optical coherence tomography (OCT) turned out to be largely preferable to colour fundus photography. However, an adequate grading instrument for Early-AMD lesions within OCT data is missing in the literature as yet. The present paper aims to fill this gap.

Methods

‘EarlyAMDRate’, an instrument for OCT-based grading of Early-AMD lesions, is presented and documented. It comprises a questionnaire assessing a given lesion with respect to its relative position and interaction with the surrounding retinal layers, its brightness, special properties and state of progression (if applicable). Furthermore, the grading procedure includes a graphical masking of the lesion within the OCT image.

Results

For a consecutive sample of N = 100 Early-AMD patients, the ‘EarlyAMDRate’ grading instrument has been applied to leading OCT scans. Examples of masked lesions and processed grading questionnaires are provided. Both raw lesion diameters and cutting sizes follow a log-normal sample distribution.

Conclusions

‘EarlyAMDRate’ allows for unprecedented detail of description for single Early-AMD lesions which is adequate to the precision of underlying OCT imaging. The obtained grading information allows for a tracking of single lesions and their properties over time as well as for the generation of well-differentiated metric phenotypes for description of Early-AMD.

Abstract Image

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EarlyAMDRate：一种基于oct评估老年性黄斑变性早期病变的分级工具。

背景和目的：早在老年性黄斑变性（AMD）的任何症状在临床上变得明显之前，这种疾病就开始于细胞外碎片沉积的积累和视网膜最外层病变的形成。为了在这些早期阶段对病变进行可靠的成像，光学相干断层扫描（OCT）在很大程度上优于彩色眼底摄影。然而，目前文献中还缺乏一种针对早期amd病变的OCT数据的适当分级工具。本文旨在填补这一空白。方法：“EarlyAMDRate”，一种基于oct的早期amd病变分级工具，被提出并记录。它包括一份问卷，评估给定病变的相对位置和与周围视网膜层的相互作用、亮度、特殊性质和进展状态（如果适用）。此外，分级过程包括在OCT图像中对病变进行图形掩蔽。结果：连续抽样N = 100例早期amd患者，“EarlyAMDRate”分级仪已应用于超前OCT扫描。提供了掩蔽病变的例子和处理过的分级问卷。原始病变直径和切割尺寸均服从对数正态样本分布。结论：“EarlyAMDRate”为单个早期amd病变提供了前所未有的详细描述，足以满足潜在OCT成像的精度。获得的分级信息允许跟踪单个病变及其随时间的特性，以及用于描述早期amd的分化良好的指标表型。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Acta Ophthalmologica 医学-眼科学

CiteScore

7.60

自引率

5.90%

发文量

433

审稿时长

6 months

期刊介绍： Acta Ophthalmologica is published on behalf of the Acta Ophthalmologica Scandinavica Foundation and is the official scientific publication of the following societies: The Danish Ophthalmological Society, The Finnish Ophthalmological Society, The Icelandic Ophthalmological Society, The Norwegian Ophthalmological Society and The Swedish Ophthalmological Society, and also the European Association for Vision and Eye Research (EVER). Acta Ophthalmologica publishes clinical and experimental original articles, reviews, editorials, educational photo essays (Diagnosis and Therapy in Ophthalmology), case reports and case series, letters to the editor and doctoral theses.