CuH-Catalyzed Regio- and Enantioselective Hydroallylation of 1-Trifluoromethylthioalkenes: Leaving Group-Dependent Stereochemistry.

IF 3.9 2区化学 Q2 CHEMISTRY, MULTIDISCIPLINARY

Chemistry - A European Journal Pub Date : 2025-03-31 DOI:10.1002/chem.202501210

Yuki Kojima, Shinichi Suda, Wataru Kanna, Yuji Nishii, Satoshi Maeda, Koji Hirano

引用次数: 0

Abstract

A copper-catalyzed regio- and enantioselective hydroallylation of 1-trifluoromethylthioalkenes with hydrosilanes and allylic electrophiles has been developed. The judicious choice of chiral ligands successfully promotes the enantioselective C(sp3)-C(sp3) bond formation at the α-position of trifluoromethylthio (SCF3) group, which is otherwise difficult to perform by other means. Experimental and computational mechanistic studies reveal that leaving groups of allylic electrophiles significantly influence the enantioselectivity as well as chemoselectivity.

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来源期刊

Chemistry - A European Journal 化学-化学综合

CiteScore

7.90

自引率

4.70%

发文量

1808

审稿时长

1.8 months

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