The role of micro-ribonucleic acid and small interfering-ribonucleic acid in precision nutrition for obesity management

IF 2.9 Q3 NUTRITION & DIETETICS

Clinical nutrition ESPEN Pub Date : 2025-03-28 DOI:10.1016/j.clnesp.2025.03.049

Wardina Humayrah , Nindy Sabrina , Megah Stefani , Nurpudji Astuti Taslim , Reggie Surya , Matthew Nathaniel Handoko , Vincent Lau , Hardinsyah Hardinsyah , Trina Ekawati Tallei , Rony Abdi Syahputra , Fahrul Nurkolis

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引用次数: 0

Abstract

Background & aims

Precision nutrition aims to tailor dietary interventions based on genetic and molecular profiles. MicroRNAs (miRNAs) and small interfering RNAs (siRNAs) are emerging as critical tools in precision obesity management. miRNAs serve as biomarkers for predicting dietary response and obesity risk, while siRNAs provide a targeted approach to silencing obesity-related genes. This review explores the mechanisms, applications, and potential of integrating miRNA and siRNA in personalized dietary strategies to combat obesity.

Methods

A comprehensive literature review was conducted using Boolean operations to identify studies on miRNAs, siRNAs, and their roles in precision nutrition. The review focused on molecular mechanisms, clinical applications, challenges, and future directions in integrating miRNA detection and siRNA therapy for obesity management.

Results

miRNAs regulate gene expression related to lipid metabolism, adipogenesis, and insulin sensitivity, with miRNA-33 and miRNA-103/107 being notable examples. siRNAs offer precise gene silencing for targets like SREBP-1c and PPARγ, addressing metabolic pathways resistant to dietary interventions. The synergistic integration of miRNAs as biomarkers and siRNAs as therapeutic tools enhances the personalization and efficacy of obesity management.

Conclusions

The dual application of miRNAs and siRNAs in precision nutrition represents a transformative approach to obesity management. While challenges such as molecular stability and delivery systems persist, advancements in RNA technology and clinical research promise to revolutionize personalized dietary strategies. Future research should focus on large-scale trials and ethical considerations to ensure equitable and effective implementation.

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微核糖核酸和小干扰核糖核酸在肥胖精准营养管理中的作用。

背景与目的：精确营养旨在根据遗传和分子特征定制饮食干预。MicroRNAs （miRNAs）和小干扰rna （sirna）正在成为精确肥胖管理的关键工具。mirna作为预测饮食反应和肥胖风险的生物标志物，而sirna提供了一种有针对性的方法来沉默肥胖相关基因。这篇综述探讨了miRNA和siRNA在个性化饮食策略中整合的机制、应用和潜力，以对抗肥胖。方法：采用布尔运算进行文献综述，识别mirna、sirna及其在精准营养中的作用。综述了miRNA检测和siRNA治疗在肥胖治疗中的分子机制、临床应用、挑战和未来方向。结果：miRNAs调节脂质代谢、脂肪形成和胰岛素敏感性相关基因的表达，以miRNA-33和miRNA-103/107为典型。sirna为SREBP-1c和PPARγ等靶标提供精确的基因沉默，解决代谢途径对饮食干预的抗性。mirna作为生物标志物和sirna作为治疗工具的协同整合增强了肥胖管理的个性化和有效性。结论：mirna和sirna在精确营养中的双重应用代表了肥胖管理的一种变革性方法。尽管分子稳定性和递送系统等挑战依然存在，但RNA技术和临床研究的进步有望彻底改变个性化的饮食策略。未来的研究应侧重于大规模试验和伦理考虑，以确保公平和有效的实施。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Clinical nutrition ESPEN NUTRITION & DIETETICS-

CiteScore

4.90

自引率

3.30%

发文量

512

期刊介绍： Clinical Nutrition ESPEN is an electronic-only journal and is an official publication of the European Society for Clinical Nutrition and Metabolism (ESPEN). Nutrition and nutritional care have gained wide clinical and scientific interest during the past decades. The increasing knowledge of metabolic disturbances and nutritional assessment in chronic and acute diseases has stimulated rapid advances in design, development and clinical application of nutritional support. The aims of ESPEN are to encourage the rapid diffusion of knowledge and its application in the field of clinical nutrition and metabolism. Published bimonthly, Clinical Nutrition ESPEN focuses on publishing articles on the relationship between nutrition and disease in the setting of basic science and clinical practice. Clinical Nutrition ESPEN is available to all members of ESPEN and to all subscribers of Clinical Nutrition.