Endocytic Uptake of Self-Assembled Iridium(III) Nanoaggregates for Holistic Treatment of Metastatic 3D Triple-Negative Breast Tumor Spheroids (Small 13/2025)

IF 13 2区材料科学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Small Pub Date : 2025-04-02 DOI:10.1002/smll.202570103

Ayushi Chaudhary, Ashwini Kumar, Nikhil Swain, Kajal Chaudhary, Himanshu Sonker, Sayari Dewan, Rutwik Anil Patil, Ritika Gautam Singh

引用次数: 0

Abstract

Breast Cancer

Triple-negative breast cancer (TNBC) presents a formidable therapeutic challenge due to its aggressive phenotype and limited treatment strategies. In article number 2406809, Ritika Gautam Singh and co-workers examine self-assembled organometallic Ir(III) nanoaggregates, which display notable cellular permeability and photoreactivity. IrL1 demonstrates nanomolar-range cytotoxicity, inducing ferroptosis-mediated cell death in TNBC cells and significantly inhibiting tumor growth in immunocompromised NOD-SCID mice, indicating strong potential for clinical translation.

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来源期刊

Small 工程技术-材料科学：综合

CiteScore

17.70

自引率

3.80%

发文量

1830

审稿时长

2.1 months

期刊介绍： Small serves as an exceptional platform for both experimental and theoretical studies in fundamental and applied interdisciplinary research at the nano- and microscale. The journal offers a compelling mix of peer-reviewed Research Articles, Reviews, Perspectives, and Comments. With a remarkable 2022 Journal Impact Factor of 13.3 (Journal Citation Reports from Clarivate Analytics, 2023), Small remains among the top multidisciplinary journals, covering a wide range of topics at the interface of materials science, chemistry, physics, engineering, medicine, and biology. Small's readership includes biochemists, biologists, biomedical scientists, chemists, engineers, information technologists, materials scientists, physicists, and theoreticians alike.