{"title":"Microtubules Disruption Alters the Cellular Structures and Mechanics Depending on Underlying Chemical Cues (Small 13/2025)","authors":"Shimaa A. Abdellatef, Hongxin Wang, Jun Nakanishi","doi":"10.1002/smll.202570096","DOIUrl":null,"url":null,"abstract":"<p><b>Microtubules Disruption</b></p><p>The roles of microtubules (MT) in cellular and nuclear morphologies, as well as mechanical responses were studied on substrates with different cell-adhesive ligand (cRGD) density. In low cRGD density, MTs and actin stress fibers aligned in elongated cells, while tangled MTs and external actin bundles formed in rounded cells on high cRGD density. More in article number 2312282, Shimaa A. Abdellatef, Hongxin Wang, and Jun Nakanishi.\n\n <figure>\n <div><picture>\n <source></source></picture><p></p>\n </div>\n </figure></p>","PeriodicalId":228,"journal":{"name":"Small","volume":"21 13","pages":""},"PeriodicalIF":13.0000,"publicationDate":"2025-04-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/smll.202570096","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Small","FirstCategoryId":"88","ListUrlMain":"https://onlinelibrary.wiley.com/doi/10.1002/smll.202570096","RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"CHEMISTRY, MULTIDISCIPLINARY","Score":null,"Total":0}
引用次数: 0
Abstract
Microtubules Disruption
The roles of microtubules (MT) in cellular and nuclear morphologies, as well as mechanical responses were studied on substrates with different cell-adhesive ligand (cRGD) density. In low cRGD density, MTs and actin stress fibers aligned in elongated cells, while tangled MTs and external actin bundles formed in rounded cells on high cRGD density. More in article number 2312282, Shimaa A. Abdellatef, Hongxin Wang, and Jun Nakanishi.
期刊介绍:
Small serves as an exceptional platform for both experimental and theoretical studies in fundamental and applied interdisciplinary research at the nano- and microscale. The journal offers a compelling mix of peer-reviewed Research Articles, Reviews, Perspectives, and Comments.
With a remarkable 2022 Journal Impact Factor of 13.3 (Journal Citation Reports from Clarivate Analytics, 2023), Small remains among the top multidisciplinary journals, covering a wide range of topics at the interface of materials science, chemistry, physics, engineering, medicine, and biology.
Small's readership includes biochemists, biologists, biomedical scientists, chemists, engineers, information technologists, materials scientists, physicists, and theoreticians alike.