Motor Cortex Activation Patterns in Both Hemispheres Induced by Motor Imagery in Patients With Right- and Left-Sided Cerebral Infarction: An fNIRS Study

Abstract

This study aimed to explore the neuroimaging basis of motor imagery (MI) in stroke rehabilitation, particularly focusing on the brain activation patterns during MI tasks. Additionally, this study may provide insights into clinical rehabilitation strategies. A total of 40 right-handed stroke patients from Zhejiang Rehabilitation Medical Center were assigned to either the right-sided or left-sided cerebral infarction group. They were right-handed and recruited from Zhejiang Rehabilitation Medical Center. A portable near-infrared brain function imaging system was used to detect changes in oxyhemoglobin concentration in the bilateral sensorimotor cortex, premotor cortex, and supplementary motor area during the MI task. Activated channels and intensity changes in brain regions under the MI state were observed and analyzed. In patients with right-sided cerebral infarction, brain activation was left-lateralized during both left- and right-limb MI. Patients with left-sided cerebral infarction exhibited left lateralization during right-limb MI and right lateralization during left-limb MI. Functional near-infrared spectroscopy was utilized to investigate the activation of motor-related brain regions during MI after stroke. These regions of interest were associated with hand motor tasks and were successfully activated during the MI task. Following infarction, the activation of the MI cortex was asymmetric. When imagining movements on the dominant-hand side, MI becomes more vivid and activates bilateral motor cortex areas.