Interventions to Reduce Inappropriate Prescribing and Administration of Psychotropic Medications for People With Neurodevelopmental Disabilities: A Systematic Review and Meta-Analysis

IF 2.1 3区医学 Q2 PSYCHOLOGY, EDUCATIONAL

Journal of Applied Research in Intellectual Disabilities Pub Date : 2025-04-01 DOI:10.1111/jar.70046

Ben Younan, Mikaela Jorgensen, Glenys Holt, Monica Cuskelly, Manya Angley, Robyn Wallace, Juanita Breen, Donna Gillies

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引用次数: 0

Abstract

Background

People with neurodevelopmental disabilities are frequently prescribed or administered psychotropic medication, particularly to manage behaviours of concern. Reducing inappropriate psychotropic use has been the target of international research and policy for several decades.

Methods

Six electronic databases were searched for interventions to reduce inappropriate prescribing or administration of psychotropics in this population.

Results

Sixteen pre–post studies were included in this review. Meta-analysis showed a significant reduction in the number of participants receiving psychotropics for medication review, multi-component interventions, workplace training, and organisational guidelines and policies (risk ratio [RR] = 0.52, 95% CI [0.43, 0.62], p < 0.00). Subgroup analysis showed significant reductions with all interventions, with no apparent differences in reduction size between intervention types.

Conclusion

Interventions reduced psychotropic use in a meta-analysis of pre–post studies. However, potential bias and high heterogeneity suggest that randomised controlled trials (RCTs) are needed for more definitive conclusions.

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来源期刊

Journal of Applied Research in Intellectual Disabilities Multiple-

CiteScore

4.70

自引率

12.50%

发文量

期刊介绍： JARID is an international, peer-reviewed journal which draws together findings derived from original applied research in intellectual disabilities. The journal is an important forum for the dissemination of ideas to promote valued lifestyles for people with intellectual disabilities. It reports on research from the UK and overseas by authors from all relevant professional disciplines. It is aimed at an international, multi-disciplinary readership. Topics covered include community living, quality of life, challenging behaviour, communication, sexuality, medication, ageing, supported employment, family issues, mental health, physical health, autism, economic issues, social networks, staff stress, staff training, epidemiology and service provision.