Fabrication of a Sensitive Electrochemical Sensor Based on Pencil Graphite Electrode Electro Spun with Poly-Sudan Black-B for Dopamine Analysis in Plasma Samples

IF 2.7 4区化学 Q2 CHEMISTRY, INORGANIC & NUCLEAR

Journal of Cluster Science Pub Date : 2025-04-02 DOI:10.1007/s10876-025-02793-3

Saba Moradi, Tahereh Momeni Isfahani, Mohammad Alimoradi

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Abstract

In this study, a composite of polyacrylonitrile and Sudan Black B was electrospun onto the surface of a pencil graphite electrode, resulting in the development of an innovative nanofiber electrochemical sensor. The proposed sensor exhibited remarkable catalytic performance when assessing dopamine concentrations through cyclic voltammetry and square wave voltammetry techniques. The morphology of the constructed sensor was characterized using scanning electron microscopy, Fourier-transform infrared spectroscopy, and thermogravimetric analysis. A linear calibration curve was established for dopamine detection in the range of 30 to 420 nanomolL^− 1, with a limit of detection determined to be 9.97 nanomolL^− 1. Furthermore, this method demonstrated satisfactory precision for the quantitative analysis of dopamine in human blood serum samples. All electrochemical evaluations of the fabricated sensors indicated consistent performance and reproducible activity. Consequently, this novel electrochemical probe is recommended for the interference-free measurement of dopamine in complex biological environments.

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来源期刊

Journal of Cluster Science 化学-无机化学与核化学

CiteScore

6.70

自引率

0.00%

发文量

166

审稿时长

3 months

期刊介绍： The journal publishes the following types of papers: (a) original and important research; (b) authoritative comprehensive reviews or short overviews of topics of current interest; (c) brief but urgent communications on new significant research; and (d) commentaries intended to foster the exchange of innovative or provocative ideas, and to encourage dialogue, amongst researchers working in different cluster disciplines.