Preparation, characterization and in vitro evaluation of poly[lactic-co-(glycolic acid)] (PLGA) nanoparticles conjugated with depolymerized hyaluronic acid for drug delivery

IF 2.2 4区化学 Q3 CHEMISTRY, PHYSICAL

Colloid and Polymer Science Pub Date : 2025-01-18 DOI:10.1007/s00396-024-05366-4

X. Janet Bertilla, S. Rupachandra

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Abstract

A drug delivery formulation is proposed to enhance the therapeutic efficacy of prednisolone while minimizing associated side effects. The method involves making a depolymerized hyaluronic acid conjugated poly(lactic-co-glycolic acid) (dp-HA-g-PLGA) copolymer with a hyaluronan-rich surface that can bind to CD44 receptors. The hydrophobic backbone of PLGA is chemically linked to partially depolymerized hyaluronic acid [dp-HA], augmenting the copolymer’s interaction with CD44 receptors. Prednisolone (PSL)-encapsulated dp-HA-g-PLGA nanoparticles (NPs) were prepared by the single emulsion technique and characterized for key parameters such as size, morphology, drug-loading efficiency, and drug release kinetics study. The average size of the PSL-encapsulated dp-HA-g-PLGA was identified as 271 nm with 74.7% encapsulation efficacy and 6.47% drug-loading efficacy. Furthermore, in vitro assays identify the biocompatibility of the nanoparticles in RAW 264.7 cells. Thus, the findings demonstrate the effectiveness of dp-HA-g-PLGA nanoparticles as a drug carrier for biomedical applications.

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来源期刊

Colloid and Polymer Science 化学-高分子科学

CiteScore

4.60

自引率

4.20%

发文量

111

审稿时长

2.2 months

期刊介绍： Colloid and Polymer Science - a leading international journal of longstanding tradition - is devoted to colloid and polymer science and its interdisciplinary interactions. As such, it responds to a demand which has lost none of its actuality as revealed in the trends of contemporary materials science.