The potential role of tranexamic acid and botulinum toxin in treating patients with acne vulgaris: a split face comparative study

IF 1.8 4区医学 Q3 DERMATOLOGY

Archives of Dermatological Research Pub Date : 2025-04-01 DOI:10.1007/s00403-025-04127-9

Mohamed Metwalli, Amina Ali Mohamed, Reham Essam

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引用次数: 0

Abstract

Background

Many causes can lead to acne, such as increased sebum production, altered sebum lipid quality from increased androgen activity, abnormal keratinization of the infundibular epithelium, and Propionibacterium acnes (P. acnes) colonizing the follicles.

Aim

The present study aimed to evaluate and compare the clinical efficacy of botulinum toxin-A vs. tranexamic acid intradermal injection in the treatment of acne vulgaris.

Methods

This split face study includes forty patients with varying grades of acne vulgaris. They were injected intradermally with tranexamic acid (20 mg/ml) on the left side for three sessions two weeks apart and once with botulinum toxin-A on the right side.

Results

After treatment, the Total Lesion Count, Comprehensive Acne severity Scale, and Clinical Erythema Assessment Scale significantly reduced, with a greater reduction in erythema on the tranexamic acid side and a greater reduction of comedones on the botulinum toxin side.

Conclusion

Tranexamic acid and botulinum toxin-A can be promising adjuvants in treating acne vulgaris by their specific mechanisms in the dermatological domain.

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来源期刊

Archives of Dermatological Research 医学-皮肤病学

CiteScore

4.10

自引率

3.30%

发文量

审稿时长

4-8 weeks

期刊介绍： Archives of Dermatological Research is a highly rated international journal that publishes original contributions in the field of experimental dermatology, including papers on biochemistry, morphology and immunology of the skin. The journal is among the few not related to dermatological associations or belonging to respective societies which guarantees complete independence. This English-language journal also offers a platform for review articles in areas of interest for dermatologists and for publication of innovative clinical trials.