Catalytic application of a bimetallic–organic framework with phosphorus acid groups in the preparation of pyrido[2,3-d]pyrimidines via cooperative vinylogous anomeric-based oxidation†

Abstract

In this work, we prepared a bimetallic–organic framework (bimetallic-MOF) using Fe/Zr as metals. Subsequently, the bimetallic-MOF was functionalized with phosphorus acid groups to serve as a heterogeneous catalyst. The catalyst was characterized using various techniques, such as field emission scanning electron microscopy (FE-SEM), energy-dispersive X-ray spectroscopy (EDS), infrared spectroscopy (FT-IR), X-ray diffraction analysis (XRD) and Brunauer–Emmett–Teller (BET) surface area analysis. Due to its suitable surface area and pore size, this heterogeneous catalyst was used for the preparation of pyrido[2,3-d]pyrimidine derivatives, achieving good yields (71–86%). Easy separation of the catalyst from the reaction medium, high yields, short reaction times and catalyst reusability are some of the characteristic advantages of multicomponent reactions.