The role of TNF in metabolic disorders and liver diseases

IF 3.7 3区医学 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY

Cytokine Pub Date : 2025-04-01 DOI:10.1016/j.cyto.2025.156933

Chuze Xu , Sohaib Hasan Abdullah Ezzi , Xiaodi Zou , Yanzhao Dong , Ahmad Alhaskawi , Haiying Zhou , Vishnu Goutham Kota , Mohamed Hasan Abdulla Hasan Abdulla , Sahar Ahmed Abdalbary , Hui Lu

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Abstract

Tumor necrosis factor (TNF) is identified as a pro-inflammatory cytokine critical to the pathology of liver disease. In the carbohydrate metabolism, TNF has been demonstrated to impede the insulin signaling pathway, thereby precipitating glucose intolerance and insulin resistance. In lipid metabolism, TNF upregulates genes implicated in fatty acid synthesis, resulting in increased lipid accumulation within the liver. In amino acid metabolism, TNF has shown to promote the gene expression for amino acid catabolism, leading to decreased protein synthesis. Additionally, TNF stimulates the production of other chemokines and inflammatory cytokines that can further exacerbate liver injury. Overall, TNF is crucial in developing liver diseases by disrupting various metabolic pathways in the liver, causing insulin resistance, lipid accumulation, and decreased protein synthesis. This review summarizes the present understanding of TNF's role in the regulation of carbohydrate, lipid and amino acid metabolism in liver disease together with its potential therapeutic implications.

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TNF在代谢紊乱和肝脏疾病中的作用

肿瘤坏死因子（TNF）被认为是一种对肝脏疾病病理至关重要的促炎细胞因子。在碳水化合物代谢中，TNF已被证明可阻碍胰岛素信号通路，从而导致葡萄糖耐受不良和胰岛素抵抗。在脂质代谢中，TNF上调与脂肪酸合成有关的基因，导致肝脏内脂质积累增加。在氨基酸代谢中，TNF已被证明可促进氨基酸分解代谢的基因表达，导致蛋白质合成减少。此外，TNF刺激其他趋化因子和炎症细胞因子的产生，可进一步加剧肝损伤。总的来说，TNF通过破坏肝脏中的各种代谢途径，引起胰岛素抵抗、脂质积累和蛋白质合成减少，在肝脏疾病的发生中起着至关重要的作用。本文综述了TNF在肝脏疾病中调节碳水化合物、脂质和氨基酸代谢的作用及其潜在的治疗意义。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Cytokine 医学-免疫学

CiteScore

7.60

自引率

2.60%

发文量

262

审稿时长

48 days

期刊介绍： The journal Cytokine has an open access mirror journal Cytokine: X, sharing the same aims and scope, editorial team, submission system and rigorous peer review. * Devoted exclusively to the study of the molecular biology, genetics, biochemistry, immunology, genome-wide association studies, pathobiology, diagnostic and clinical applications of all known interleukins, hematopoietic factors, growth factors, cytotoxins, interferons, new cytokines, and chemokines, Cytokine provides comprehensive coverage of cytokines and their mechanisms of actions, 12 times a year by publishing original high quality refereed scientific papers from prominent investigators in both the academic and industrial sectors. We will publish 3 major types of manuscripts: 1) Original manuscripts describing research results. 2) Basic and clinical reviews describing cytokine actions and regulation. 3) Short commentaries/perspectives on recently published aspects of cytokines, pathogenesis and clinical results.