Multi-active-site antibacterial modification of dopamine-hyaluronic acid hydrogel with N-halamine for skin tissue engineering

IF 10.7 1区化学 Q1 CHEMISTRY, APPLIED

Carbohydrate Polymers Pub Date : 2025-03-30 DOI:10.1016/j.carbpol.2025.123565

Chenghao Li , Saren Gerile , Nan Du , Liang Zou , Zhiqiang Wang , Yanfang Liu , Jili Hou , Kuntong Song , Yuanhao Xiao , Hui Ren , Jing Kang , Alideertu Dong , Run Xu

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引用次数: 0

Abstract

Antibacterial hydrogels have attracted much attention in skin tissue engineering due to their superior ability to prevent infection. In this study, we developed an antibacterial hydrogel using a multi-active site N-halamine-modified dopamine-hyaluronic acid hydrogel. The in vitro antibacterial efficacy of the hydrogel exhibited 99.99 % against both Gram-negative Escherichia coli and Gram-positive Staphylococcus aureus, while also demonstrating excellent biocompatibility. Furthermore, in Escherichia coli-infected skin wounds, the hydrogels effectively suppressed infection and significantly accelerated wound healing. These findings suggest that N-halamine-modified dopamine-hyaluronic acid antibacterial hydrogels have great potential as wound dressings for preventing infection and promoting the healing of infected wounds.

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来源期刊

Carbohydrate Polymers 化学-高分子科学

CiteScore

22.40

自引率

8.00%

发文量

1286

审稿时长

47 days

期刊介绍： Carbohydrate Polymers stands as a prominent journal in the glycoscience field, dedicated to exploring and harnessing the potential of polysaccharides with applications spanning bioenergy, bioplastics, biomaterials, biorefining, chemistry, drug delivery, food, health, nanotechnology, packaging, paper, pharmaceuticals, medicine, oil recovery, textiles, tissue engineering, wood, and various aspects of glycoscience. The journal emphasizes the central role of well-characterized carbohydrate polymers, highlighting their significance as the primary focus rather than a peripheral topic. Each paper must prominently feature at least one named carbohydrate polymer, evident in both citation and title, with a commitment to innovative research that advances scientific knowledge.