Nanoarchitectonics of polyaniline-poly(vinyl pyrrolidone)-graphene composite for the electrochemical sensing of ciprofloxacin and uric acid

IF 5.5 3区工程技术 Q1 ENGINEERING, CHEMICAL

Journal of the Taiwan Institute of Chemical Engineers Pub Date : 2025-04-02 DOI:10.1016/j.jtice.2025.106103

Suguna Perumal , Raji Atchudan , Katarzyna Krukiewicz , Angelika Banaś , Deivasigamani Ranjith Kumar , Hyunjung Lee , Wonmok Lee

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引用次数: 0

Abstract

Background

Ciprofloxacin (Cif) is a fluoroquinolone-based antibiotic that is prescribed for patients infected by gram-positive and gram-negative aerobic pathogens. Owing to its medical applications, target-specific determination of Cif in urine samples is challenging due to the presence of uric acid (UA) as an interference.

Methods

Polyaniline-poly(vinylpyrrolidone)-graphene (GPA-PVPy) composite is reported as an electrode material for sensing Cif in the presence of UA. Graphite-polyaniline (GPA) was prepared by oxidative polymerization of aniline at 0–5 °C over 12 h. Subsequently, GPA was used to polymerize vinyl pyrrolidone (VPy) by a free radical polymerization composite in a sonication bath at 70 °C for 6 h. Composites (GPA and GPA-PVPy) are characterized using field-emission scanning electron microscopy, X-ray diffraction, Raman spectroscopy, X-ray photoelectron spectroscopy, and thermogravimetric analysis. GPA and GPA-PVPy composites were coated on a glassy carbon (GC) electrode and investigated by cyclic voltammetry to verify their sensitivity towards Cif in the presence of UA as a major interference. Electrochemical impedance spectroscopy was used to estimate the electron transfer rate of composite electrodes.

Significant Findings

Using GPA-PVPy/GC electrode, similar concentrations of UA and Cif (10 – 310 μM) were simultaneously detected in a human urine sample with excellent sensitivity (0.007 μAμM^-1 (UA) and 0.0048 μAμM^-1 (Cif)) and low limit of detection (4.37 μM (UA) and 9.0 μM (Cif)), respectively showing its applicability in medical analysis.

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来源期刊

Journal of the Taiwan Institute of Chemical Engineers 工程技术-工程：化工

CiteScore

9.10

自引率

14.00%

发文量

362

审稿时长

35 days

期刊介绍： Journal of the Taiwan Institute of Chemical Engineers (formerly known as Journal of the Chinese Institute of Chemical Engineers) publishes original works, from fundamental principles to practical applications, in the broad field of chemical engineering with special focus on three aspects: Chemical and Biomolecular Science and Technology, Energy and Environmental Science and Technology, and Materials Science and Technology. Authors should choose for their manuscript an appropriate aspect section and a few related classifications when submitting to the journal online.