Mechanistic insights and therapeutic approaches in tic disorders: The distinctive role of ethnomedicine and modern medical interventions

IF 7.5 1区医学 Q1 BEHAVIORAL SCIENCES

Neuroscience and Biobehavioral Reviews Pub Date : 2025-03-30 DOI:10.1016/j.neubiorev.2025.106130

Mingyue Zhang , Yinghui Zhang , Yan Chen , Zhifeng Cen , Ji Li , Shasha Li , Haipeng Li , Lisheng Wan , Xue Xiao , Qinqiang Long

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引用次数: 0

Abstract

Tic disorders (TDs) are a class of neurodevelopmental disorders that have received considerable scientific attention. The genesis of TDs is increasingly understood as a complex interplay of neurobiological, genetic, and immunological factors. Animal model studies have elucidated the pathophysiology of TDs, paving the way for innovative therapeutic approaches. This review provides a comprehensive analysis of the etiologic basis, experimental framework, and treatment strategies for TDs, highlighting the contributions of ethnomedicine and modern medicine. Our synthesis aims to deepen the understanding of the disease and spur the development of superior treatments. In addition, we present new insights and hypotheses for the future management of TDs, emphasizing the need for continued research into their etiology and progression, as well as the pursuit of more effective therapies. We advocate personalized, holistic care strategies that focus on symptom relief and improving patients' quality of life. Overall, this review provides a critical compendium for TD researchers and practitioners to help navigate the complexities of these disorders.

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抽动障碍的机制见解和治疗方法：民族医学和现代医学干预的独特作用

抽动障碍（Tic disorders, TDs）是一类神经发育障碍，受到了相当多的科学关注。TDs的发生被越来越多地理解为神经生物学、遗传和免疫因素的复杂相互作用。动物模型研究阐明了TDs的病理生理机制，为创新治疗方法铺平了道路。本文综述了TDs的病因基础、实验框架和治疗策略，重点介绍了民族医学和现代医学对TDs的贡献。我们的合成旨在加深对这种疾病的理解，并促进更好治疗方法的发展。此外，我们对TDs的未来管理提出了新的见解和假设，强调需要继续研究其病因和进展，以及寻求更有效的治疗方法。我们提倡个性化的整体护理策略，专注于症状缓解和改善患者的生活质量。总的来说，这篇综述为TD研究人员和从业者提供了一个重要的纲要，以帮助他们驾驭这些疾病的复杂性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Neuroscience and Biobehavioral Reviews 医学-行为科学

CiteScore

14.20

自引率

3.70%

发文量

466

审稿时长

6 months

期刊介绍： The official journal of the International Behavioral Neuroscience Society publishes original and significant review articles that explore the intersection between neuroscience and the study of psychological processes and behavior. The journal also welcomes articles that primarily focus on psychological processes and behavior, as long as they have relevance to one or more areas of neuroscience.