Magnetic scaffolds for the mechanotransduction stimulation in tendon tissue regeneration

IF 8.7 1区医学 Q1 ENGINEERING, BIOMEDICAL

Materials Today Bio Pub Date : 2025-03-26 DOI:10.1016/j.mtbio.2025.101699

Eleonora Bianchi , Manuel Bañobre-Lopez , Marco Ruggeri , Elena Del Favero , Barbara Vigani , Caterina Ricci , Cinzia Boselli , Antonia Icaro Cornaglia , Martin Albino , Claudio Sangregorio , Alessandro Lascialfari , Jessica Zanovello , Eugenio Jannelli , Francesco Claudio Pavesi , Silvia Rossi , Luca Casettari , Giuseppina Sandri

{"title":"Magnetic scaffolds for the mechanotransduction stimulation in tendon tissue regeneration","authors":"Eleonora Bianchi , Manuel Bañobre-Lopez , Marco Ruggeri , Elena Del Favero , Barbara Vigani , Caterina Ricci , Cinzia Boselli , Antonia Icaro Cornaglia , Martin Albino , Claudio Sangregorio , Alessandro Lascialfari , Jessica Zanovello , Eugenio Jannelli , Francesco Claudio Pavesi , Silvia Rossi , Luca Casettari , Giuseppina Sandri","doi":"10.1016/j.mtbio.2025.101699","DOIUrl":null,"url":null,"abstract":"<div><div>Nowadays, tendon injuries represent a global health issue that annually affects millions of individuals. An innovative approach for their treatment is represented by the development of tissue engineered scaffolds able to support the host cells adhesion, differentiation, and proliferation. However, the scaffold alone could be insufficient to guarantee an improvement of healing control. Magnetite nanoparticles (Fe<sub>3</sub>O<sub>4</sub> NPs) are gaining interest due to their unique properties. In particular, when combined with bio-mimetic scaffolds, they should lead to the cells mechano-stimulation, improving the tenogenic differentiation and allowing a deeper tissue reparation.</div><div>The aim of this work is the study and the development of scaffolds based on polyhydroxybutyrate and gelatin and doped with Fe<sub>3</sub>O<sub>4</sub> NPs. The scaffolds are characterized by an aligned fibrous shape able to mimic the tendon fascicles. Moreover, they possess a superparamagnetic behavior and a slow degradation rate that should guarantee structural support during the tissue regeneration. The magnetic scaffolds promote cell proliferation and alignment onto the matrix, in particular when combined with the application of an external magnetic field. Also, the cells are able to differentiate and produce collagen I extracellular matrix. Finally, the magnetic scaffold <em>in vivo</em> promotes complete tissue healing after 1 week of treatment when combined with the external magnetic stimulation.</div></div>","PeriodicalId":18310,"journal":{"name":"Materials Today Bio","volume":"32 ","pages":"Article 101699"},"PeriodicalIF":8.7000,"publicationDate":"2025-03-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Materials Today Bio","FirstCategoryId":"5","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S2590006425002583","RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"ENGINEERING, BIOMEDICAL","Score":null,"Total":0}

引用次数: 0

Abstract

Nowadays, tendon injuries represent a global health issue that annually affects millions of individuals. An innovative approach for their treatment is represented by the development of tissue engineered scaffolds able to support the host cells adhesion, differentiation, and proliferation. However, the scaffold alone could be insufficient to guarantee an improvement of healing control. Magnetite nanoparticles (Fe₃O₄ NPs) are gaining interest due to their unique properties. In particular, when combined with bio-mimetic scaffolds, they should lead to the cells mechano-stimulation, improving the tenogenic differentiation and allowing a deeper tissue reparation.

The aim of this work is the study and the development of scaffolds based on polyhydroxybutyrate and gelatin and doped with Fe₃O₄ NPs. The scaffolds are characterized by an aligned fibrous shape able to mimic the tendon fascicles. Moreover, they possess a superparamagnetic behavior and a slow degradation rate that should guarantee structural support during the tissue regeneration. The magnetic scaffolds promote cell proliferation and alignment onto the matrix, in particular when combined with the application of an external magnetic field. Also, the cells are able to differentiate and produce collagen I extracellular matrix. Finally, the magnetic scaffold in vivo promotes complete tissue healing after 1 week of treatment when combined with the external magnetic stimulation.

Abstract Image

查看原文本刊更多论文

求助全文

约1分钟内获得全文求助全文

来源期刊

Materials Today Bio Multiple-

CiteScore

8.30

自引率

4.90%

发文量

303

审稿时长

30 days

期刊介绍： Materials Today Bio is a multidisciplinary journal that specializes in the intersection between biology and materials science, chemistry, physics, engineering, and medicine. It covers various aspects such as the design and assembly of new structures, their interaction with biological systems, functionalization, bioimaging, therapies, and diagnostics in healthcare. The journal aims to showcase the most significant advancements and discoveries in this field. As part of the Materials Today family, Materials Today Bio provides rigorous peer review, quick decision-making, and high visibility for authors. It is indexed in Scopus, PubMed Central, Emerging Sources, Citation Index (ESCI), and Directory of Open Access Journals (DOAJ).