Prolonged noise exposure-induced auditory threshold shifts in wistar rats: Proposal of an experimental exposure protocol based on noise dose

IF 1.7 4区医学 Q2 OTORHINOLARYNGOLOGY

Brazilian Journal of Otorhinolaryngology Pub Date : 2025-04-02 DOI:10.1016/j.bjorl.2025.101570

Ana Carolina Odorizzi Zica , Gabriela Ribeiro Novanta , Maria Luiza Queiroz Sampaio , Rafael Rocha de Andrade , Lucieny Silva Martins Serra , André Luiz Lopes Sampaio

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引用次数: 0

Abstract

Objective

The aim of the present study was to evaluate the effects of different doses of broadband white noise in a group of Wistar rats.

Methods

The sample consisted of 6 male Wistar rats. The animals went through sequential exposures at the intensity of 95 dB for 60 min, 100 dB for 60 min and 100 dB for 120 min. Audiological evaluation was performed by Distortion Product Otoacoustic Emissions (DPOAE) exams at frequencies from 2 to 12 KHz, after each exposure/pause protocol. Statistical analysis was performed based on the values found in the DPOAE and Signal-to-Noise Ratio (S/N) in the nine exams performed over 50 days of research.

Results

The study concluded that there was a compound threshold shift induced by long-term sequential noise exposure at the intensity of 100 dB for 60 min and for 120 min, with a “plateau/’ observed in the DPOAE and S/N results that coincide with the exposure period of 6 days at the intensity of 100 dB for 120 min.

Conclusion

Thus, we established the proposal of an exposure protocol for research with wistar rats exposed to noise.

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来源期刊

Brazilian Journal of Otorhinolaryngology OTORHINOLARYNGOLOGY-

CiteScore

3.00

自引率

0.00%

发文量

205

审稿时长

4-8 weeks

期刊介绍： Brazilian Journal of Otorhinolaryngology publishes original contributions in otolaryngology and the associated areas (cranio-maxillo-facial surgery and phoniatrics). The aim of this journal is the national and international divulgation of the scientific production interesting to the otolaryngology, as well as the discussion, in editorials, of subjects of scientific, academic and professional relevance. The Brazilian Journal of Otorhinolaryngology is born from the Revista Brasileira de Otorrinolaringologia, of which it is the English version, created and indexed by MEDLINE in 2005. It is the official scientific publication of the Brazilian Association of Otolaryngology and Cervicofacial Surgery. Its abbreviated title is Braz J Otorhinolaryngol., which should be used in bibliographies, footnotes and bibliographical references and strips.