Selenium-enriched Kazachstania unispora KU2 ameliorates patulin-induced intestinal injury in mice by mediating the gut microbiota and selenoprotein P synthesis

IF 12.2 1区环境科学与生态学 Q1 ENGINEERING, ENVIRONMENTAL

Journal of Hazardous Materials Pub Date : 2025-04-01 DOI:10.1016/j.jhazmat.2025.138129

Furong Wang , Xian Wang , Yilei Xiao , Ruixin Liu , Xiaoben Li , Jinpeng Hu , Wei Song , Kewei Feng , Yahong Yuan , Tianli Yue

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引用次数: 0

Abstract

Patulin (PAT) is a foodborne mycotoxin that causes intestinal injury. Selenium (Se)-enriched Kazachstania unispora (K. unispora) KU2 is a novel dietary Se carrier, and Se exerts important roles in intestinal homeostasis. Here, we examined the ameliorative effects of K. unispora KU2 and Se-enriched K. unispora KU2 against PAT-induced intestinal injury. Results indicated that both K. unispora KU2 and Se-enriched K. unispora KU2 alleviated PAT-induced inflammatory infiltration, disrupted gut microbiota, and associated metabolic imbalances, indicating the probiotic potential of this strain. Se-enriched K. unispora KU2 exhibited more pronounced remediation comparable to K. unispora KU2, revealing the promoting effect of Se. Furthermore, Se-enriched K. unispora KU2 restored intestinal Se homeostasis by upregulating SEPP1 levels to mitigate intestinal injury. Using pseudo germ-free mouse models, we confirmed that gut microbiota was required for the improvement in SEPP1 synthesis and intestinal transport mediated by Se-enriched K. unispora KU2. These findings elucidate a mechanism whereby the alleviation of PAT-induced intestinal injury by Se-enriched K. unispora KU2 is linked to upregulation of SEPP1 by the gut microbiota, suggesting its potential therapeutic relevance for intestinal diseases.

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来源期刊

Journal of Hazardous Materials 工程技术-工程：环境

CiteScore

25.40

自引率

5.90%

发文量

3059

审稿时长

58 days

期刊介绍： The Journal of Hazardous Materials serves as a global platform for promoting cutting-edge research in the field of Environmental Science and Engineering. Our publication features a wide range of articles, including full-length research papers, review articles, and perspectives, with the aim of enhancing our understanding of the dangers and risks associated with various materials concerning public health and the environment. It is important to note that the term "environmental contaminants" refers specifically to substances that pose hazardous effects through contamination, while excluding those that do not have such impacts on the environment or human health. Moreover, we emphasize the distinction between wastes and hazardous materials in order to provide further clarity on the scope of the journal. We have a keen interest in exploring specific compounds and microbial agents that have adverse effects on the environment.