Enhanced detection of envelope-following responses for objective fitting of cochlear-implant users.

Julian Matthias Schott, Robin Gransier, Marc Moonen, Jan Wouters
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Abstract

Objective: Electrically evoked auditory steady-state responses (EASSRs) are potential neural responses for objectively determining stimulation parameters of cochlear implants (CIs). Unfortunately, they are difficult to detect in electroencephalography (EEG) recordings due to the electrical stimulation artifacts of the CI. This study investigates a novel stimulation paradigm hypothesized to improve artifact removal efficacy via system identification (SI), and therefore to improve response detection and clinical applicability.

Approach: An amplitude-modulated (AM) CI stimulation pulse train with a step-wise increase in modulation frequency is created (referred to as SWEEP stimulation). Another stimulation is created by randomly shuffling modulation frequencies of the SWEEP stimulation (referred to as Shuffled- SWEEP stimulation). AM pulse trains with fixed modulation frequency (referred to as conventional AM stimulation), which elicit EASSRs, are also created for comparison. EEG data is collected from four CI users. A supra-threshold stimulation condition is used to investigate whether the SWEEP and Shuffled- SWEEP stimulation can elicit envelope-following responses (EFRs). A sub- threshold stimulation condition allows the collection of artifact-only EEG data, which is used to compare the SI accuracy on recordings from the SWEEP and the conventional AM stimulation.

Main results: In all CI users, neural responses, following the SWEEP, Shuffled-SWEEP, and conventional AM stimulation are detected after artifact removal with SI. The validation with artifact-only EEG data shows higher F1 scores when comparing recordings with SWEEP stimulation (F1 = 0.9) to recordings with conventional AM stimulation (F1 = 0.82).

Significance: Being able to accurately identify the response within one EEG recording enables the development of effective, online, objective fitting protocols. The increased neural response detection sensitivity with SWEEP stimulation reduces clinical recording time on average by a factor of 2.07. Detecting EFRs following complex stimulation paradigms offers a potential advancement in the systematic assessment of the temporal envelope processing in CI users.

增强对包络跟踪反应的检测,以便对人工耳蜗用户进行客观评估。
目的:电诱发听觉稳态反应(EASSRs)是客观确定人工耳蜗(CIs)刺激参数的潜在神经反应。不幸的是,由于CI的电刺激伪影,它们很难在脑电图(EEG)记录中检测到。本研究研究了一种新的刺激模式,假设通过系统识别(SI)来提高伪影去除效果,从而提高反应检测和临床适用性。方法:创建调制频率逐步增加的调幅(AM) CI刺激脉冲序列(称为SWEEP刺激)。另一种刺激是通过随机变换扫描刺激的调制频率产生的(称为shuffle - SWEEP刺激)。具有固定调制频率的AM脉冲序列(称为常规AM刺激)也被创建用于比较,这些脉冲序列会引发EASSRs。EEG数据来自4个CI用户。采用超阈刺激条件研究了SWEEP和shuffed - SWEEP刺激是否能引起包络跟随反应(EFRs)。亚阈值刺激条件允许只收集伪象脑电图数据,用于比较扫描和常规调幅刺激记录的SI精度。主要结果:在所有CI使用者中,在使用SI去除伪影后,在SWEEP、shuffed -SWEEP和常规AM刺激后检测到神经反应。与常规AM刺激(F1 = 0.82)相比,扫描刺激(F1 = 0.9)记录的伪影EEG数据验证显示更高的F1分数。意义:能够在一次脑电图记录中准确识别反应,可以开发有效的、在线的、客观的拟合方案。扫描刺激增加的神经反应检测灵敏度平均减少了2.07倍的临床记录时间。检测复杂刺激模式下的efr为系统评估CI用户的时间包络处理提供了一个潜在的进步。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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