CD 14 Expression in Urothelial Carcinoma of The Urinary Bladder (Histopathological and Immunohistochemical Study).

Q2 Medicine

Asian Pacific Journal of Cancer Prevention Pub Date : 2025-03-01 DOI:10.31557/APJCP.2025.26.3.889

Nora T El-Zohery, Yousra R Shalaby, Ayman I Kasem, Rasha R Mostafa

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引用次数: 0

Abstract

Background: Egypt has a significantly higher prevalence of cancer bladder than the rest of the world. CD-14 antigen is involved in Toll-like receptor-mediated signaling pathways in inflammatory tumor microenvironment which promote tumor development and proliferation. There have been few studies on CD14 antigen effect on urothelial carcinoma of the urinary bladder. This study aimed to evaluate the role of CD14 in prognosis of uurothelial carcinoma of the urinary bladder and its association with the tumor progression.

Material and methods: This retrospective cross-sectional study included fifty-one cases of urothelial carcinoma obtained either by cystoscopic biopsies or radical cystectomies. They were immunohistochemically stained using anti- CD14 antibody. Statistical correlations between CD14 expression and available clinicopathological data were done.

Results: Positive immunoexpression of CD14 was noted in 84.3% of all cases, showing scores 1, 2 & 3 in 9.8%, 29.4%, and 45.1% of cases, respectively. While negative immunoexpression was noted in 15.7% of cases and was scored as 0. A statistically significant correlation was noticed between CD14 immunohistochemical expression and each of the tumor grade, pathological tumor stage, status of muscle invasion, and pathological lymph node stage (P value=0.045, 0.030, 0.001, and 0.008 respectively). However, no statistically significant correlation was noted between CD14 immunohistochemical expression and each of the two-year survival rates in radical cystectomy cases and the mortality rate after exclusion of the postoperative complications (P value = 0.114 & 0.156 respectively).

Conclusion: The intensity of CD14 expression was weak and even lost in high-grade and late-stage urothelial bladder carcinoma cases, while low-grade urothelial carcinoma cases showed CD14 overexpression. Accordingly, the significance of therapeutic approaches targeting CD14 in high-grade and late-stage urothelial bladder carcinoma shall be questionable.

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来源期刊

Asian Pacific Journal of Cancer Prevention 医学-肿瘤学

CiteScore

2.80

自引率

0.00%

发文量

779

审稿时长

3 months

期刊介绍： Cancer is a very complex disease. While many aspects of carcinoge-nesis and oncogenesis are known, cancer control and prevention at the community level is however still in its infancy. Much more work needs to be done and many more steps need to be taken before effective strategies are developed. The multidisciplinary approaches and efforts to understand and control cancer in an effective and efficient manner, require highly trained scientists in all branches of the cancer sciences, from cellular and molecular aspects to patient care and palliation. The Asia Pacific Organization for Cancer Prevention (APOCP) and its official publication, the Asia Pacific Journal of Cancer Prevention (APJCP), have served the community of cancer scientists very well and intends to continue to serve in this capacity to the best of its abilities. One of the objectives of the APOCP is to provide all relevant and current scientific information on the whole spectrum of cancer sciences. They aim to do this by providing a forum for communication and propagation of original and innovative research findings that have relevance to understanding the etiology, progression, treatment, and survival of patients, through their journal. The APJCP with its distinguished, diverse, and Asia-wide team of editors, reviewers, and readers, ensure the highest standards of research communication within the cancer sciences community across Asia as well as globally. The APJCP publishes original research results under the following categories: -Epidemiology, detection and screening. -Cellular research and bio-markers. -Identification of bio-targets and agents with novel mechanisms of action. -Optimal clinical use of existing anti-cancer agents, including combination therapies. -Radiation and surgery. -Palliative care. -Patient adherence, quality of life, satisfaction. -Health economic evaluations.